Institute for Biomedical Aging Research, Austrian Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
Vaccine. 2010 Apr 30;28(20):3511-5. doi: 10.1016/j.vaccine.2010.03.024. Epub 2010 Mar 21.
Because of decreased immune functions of older people booster intervals of 3 years - instead of 5 - are recommended for tick-borne encephalitis (TBE) vaccinations for persons >or=60 years in Austria. So far, no comparative data on the immune-responsiveness of the age group 50-59 years are available. We therefore investigated the antibody titers and booster responses (in ELISA and neutralization assays) for the age groups 50-59, 60-69, and >69 years in comparison to a control group below 30 years. The age group 50-59 years displayed the same decreased antibody response, also characteristic for persons 60 years and older. Although antibody concentrations were lower after 5-7 years compared to 3-4 year intervals, antibodies were still detectable and could be sufficiently increased by booster shots in the vast majority of persons. Our results clearly indicate that the responsiveness of the immune system to vaccination is already impaired at the age of 50.
由于老年人的免疫功能下降，奥地利建议 >or=60 岁的人接种蜱传脑炎（TBE）疫苗的加强针间隔为 3 年，而非 5 年。到目前为止，对于 50-59 岁年龄组的免疫反应性，尚无比较数据。因此，我们调查了 50-59 岁、60-69 岁和 >69 岁年龄组与 30 岁以下对照组的抗体滴度和加强针反应（ELISA 和中和试验）。50-59 岁年龄组的抗体反应与 60 岁及以上人群的特征相同，也呈下降趋势。尽管与 3-4 年的间隔相比，5-7 年后的抗体浓度较低，但在绝大多数人身上，抗体仍然可以检测到，并可通过加强针充分增加。我们的研究结果清楚地表明，免疫系统对疫苗接种的反应性在 50 岁时已经受损。
