Ganz Tomas
Departments of Medicine and Pathology, David Geffen School of Medicine University of California, Los Angeles, California 90095-1690, USA.
Curr Opin Hematol. 2004 Jul;11(4):251-4. doi: 10.1097/00062752-200407000-00004.
Hepcidin is a recently discovered hepatic peptide that regulates intestinal iron absorption as well as maternal-fetal iron transport across the placenta. It probably also affects the release of iron from hepatic stores and from macrophages involved in the recycling of iron from hemoglobin. Connecting iron metabolism to innate immunity, hepcidin is a key mediator of hypoferremia of inflammation.
The essential role of hepcidin in iron metabolism is being elucidated through mouse and human genetics, biochemistry, and cell biology.
Studies of hepcidin are leading to fundamental understanding of iron homeostasis and pointing to potential treatments for hemochromatosis and anemia of inflammation (anemia of chronic disease).
铁调素是一种最近发现的肝脏肽，它调节肠道铁吸收以及母体-胎儿间通过胎盘的铁转运。它可能还会影响肝脏铁储备以及参与血红蛋白中铁循环的巨噬细胞释放铁。铁调素将铁代谢与先天免疫联系起来，是炎症性低铁血症的关键介质。
通过小鼠和人类遗传学、生物化学及细胞生物学研究，铁调素在铁代谢中的重要作用正逐渐明晰。
对铁调素的研究正促使人们对铁稳态有更基本的认识，并为血色病和炎症性贫血（慢性病贫血）指明潜在的治疗方法。
