Gerber J, Tauber S C, Armbrecht I, Schmidt H, Brück W, Nau R
Department of Neurology, RWTH University Hospital, Aachen, Germany.
Neurology. 2009 Sep 29;73(13):1026-32. doi: 10.1212/WNL.0b013e3181b9c892.
Neurogenesis is increased in experimental models of bacterial meningitis. In this study, neurogenesis was examined after bacterial infection of the CNS, and after stroke and brain trauma in humans.
Brain sections of patients after death from bacterial meningitis, stroke, or brain trauma and from autopsy cases after death from nonneurologic diseases were investigated by immunohistochemistry.
In the dentate gyrus, the density of proliferating cellular nuclear antigen-expressing cells was higher after bacterial meningitis compared to the control group (p = 0.0075). Furthermore, the number of cells expressing the immature neuronal marker proteins TUC-4 and doublecortin were increased in brain sections of patients after death from meningitis compared to control cases (p = 0.0067 and p = 0.045). After stroke and brain trauma, higher densities of proliferating cells were observed (p = 0.031 and p = 0.018), while an increase of TUC-4-expressing cells was detected after stroke only (p = 0.0012 and p = 0.47).
The increased proliferation of neural progenitors suggests an endogenous mechanism in response to noxious stimuli. Stimulation of neurogenesis might help to alleviate the consequences of neuronal destruction in bacterial meningitis and other diseases of the brain.
在细菌性脑膜炎的实验模型中神经发生增加。在本研究中，对中枢神经系统细菌感染后、人类中风和脑外伤后的神经发生情况进行了检测。
通过免疫组织化学对因细菌性脑膜炎、中风或脑外伤死亡患者的脑切片以及因非神经系统疾病死亡的尸检病例的脑切片进行研究。
在齿状回中，与对照组相比，细菌性脑膜炎后表达增殖细胞核抗原的细胞密度更高（p = 0.0075）。此外，与对照病例相比，死于脑膜炎患者的脑切片中表达未成熟神经元标记蛋白TUC - 4和双皮质素的细胞数量增加（p = 0.0067和p = 0.045）。中风和脑外伤后，观察到增殖细胞密度更高（p = 0.031和p = 0.018），而仅在中风后检测到表达TUC - 4的细胞增加（p = 0.0012和p = 0.47）。
神经祖细胞增殖增加提示了一种应对有害刺激的内源性机制。刺激神经发生可能有助于减轻细菌性脑膜炎和其他脑部疾病中神经元破坏的后果。
