喂食、饥饿、酸中毒、糖尿病、受伤及脓毒症大鼠肺脏中的谷氨酰胺合成活性。
Glutamine-synthesizing activity in lungs of fed, starved, acidotic, diabetic, injured and septic rats.
作者信息
Ardawi M S
机构信息
Department of Clinical Biochemistry, College of Medicine and Allied Sciences, King Abdulaziz University, Jeddah, Saudi Arabia.
出版信息
Biochem J. 1990 Sep 15;270(3):829-32. doi: 10.1042/bj2700829.
Abstract
The maximal catalytic activity of glutamine synthetase was measured in lung homogenates of the rat (being 5.46 +/- 0.29 mumol/min per g wet wt. or 31.70 +/- 2.62 nmol/min per mg of protein at 37 degrees C, in fed animals). The activity is similar to that of liver, but 16-fold higher than that in quadriceps muscles. Chronic (NH4Cl-induced) or acute (HCl-induced) metabolic acidosis had no effects on enzyme activity, but there was a marked increase in the activity of glutamine synthetase in starved (30-40%), streptozotocin-diabetic (17%), dexamethasone-treated (18-22%), laparotomized (25-27%) and septic rats (24-45%).
摘要
在大鼠肺匀浆中测定了谷氨酰胺合成酶的最大催化活性（在37℃下，喂食动物的活性为每克湿重5.46±0.29微摩尔/分钟或每毫克蛋白质31.70±2.62纳摩尔/分钟）。该活性与肝脏相似，但比股四头肌中的活性高16倍。慢性（氯化铵诱导）或急性（盐酸诱导）代谢性酸中毒对酶活性无影响，但在饥饿（30 - 40%）、链脲佐菌素诱导糖尿病（17%）、地塞米松处理（18 - 22%）、剖腹手术（25 - 27%）和脓毒症大鼠（24 - 45%）中，谷氨酰胺合成酶的活性显著增加。
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