酸中毒时肌肉的谷氨酰胺合成酶活性
Glutamine synthetase activity of muscle in acidosis.
作者信息
King P A, Goldstein L, Newsholme E A
出版信息
Biochem J. 1983 Nov 15;216(2):523-5. doi: 10.1042/bj2160523.
Abstract
Metabolic acidosis stimulates the rate of glutamine release from muscle, and this in turn is used by the kidney in acid-base balance. NH4Cl, HCl or diabetic ketoacidosis increases the maximum activity of glutamine synthetase in skeletal muscle. Starvation and administration of adrenal steroids also increase the activity of the enzyme in muscle.
摘要
代谢性酸中毒会刺激肌肉中谷氨酰胺的释放速率，而这反过来又被肾脏用于酸碱平衡。氯化铵、盐酸或糖尿病酮症酸中毒会增加骨骼肌中谷氨酰胺合成酶的最大活性。饥饿和给予肾上腺类固醇也会增加肌肉中该酶的活性。
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