Alimentary Pharmabiotic Centre, Department of Medicine, University College Cork, Cork, Ireland.
Curr Opin Gastroenterol. 2010 Jan;26(1):53-60. doi: 10.1097/MOG.0b013e328332c977.
Disorders of colonic motor and sensory function are common among children and adults and pose significant diagnostic and therapeutic challenges; the purpose of this review, therefore, was to critically assess the recent literature on this topic.
Considerable progress has been made at the ultrastructural, molecular and electrophysiological level in understanding the normal functions of the muscles, nerves and interstitial cells that generate and control colonic motility. Furthermore, abnormalities in these cell types and in the interstitial cells of Cajal, in particular, have been identified in a number of disease states. Testing of colonic motor and sensory function in clinical practice continues to be a challenge due, in part, not only to the technical issues presented by accessing the organ but also to the intrinsic variability of its physiology. These have not been auspicious times for advances in the therapy of disturbed colonic motility; new agents or new applications for 'old' agents continue to be explored as are more innovative approaches such as those based on neural stimulation and cell therapy.
Considerable progress has been made in understanding the basic pathophysiology of colonic dysmotility; clinical diagnostics and therapeutics continue to lag behind.
结肠运动和感觉功能障碍在儿童和成人中很常见，给诊断和治疗带来了重大挑战；因此，本次综述的目的是批判性地评估该主题的最新文献。
在理解产生和控制结肠运动的肌肉、神经和间质细胞的正常功能方面，在超微结构、分子和电生理学水平上已经取得了相当大的进展。此外，在许多疾病状态下，已经发现这些细胞类型和 Cajal 间质细胞存在异常。由于不仅要考虑到获取器官带来的技术问题，还要考虑到其生理学的固有变异性，因此在临床实践中测试结肠运动和感觉功能仍然是一个挑战。由于新的治疗方法或“旧”药物的新应用仍在探索中，例如基于神经刺激和细胞治疗的更具创新性的方法，因此，治疗紊乱性结肠运动的进展并不顺利。
