细颗粒物与氧化 DNA 损伤之间的关联可能在高血压患者中受到修饰。
Association between fine particulate matter and oxidative DNA damage may be modified in individuals with hypertension.
机构信息
National Center for Environmental Assessment, U.S. Environmental Protection Agency, Research Triangle Park, NC, USA.
出版信息
J Occup Environ Med. 2009 Oct;51(10):1158-66. doi: 10.1097/JOM.0b013e3181b967aa.
Abstract
OBJECTIVE
To investigate the association between particulate matter (PM2.5) and urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) in hypertensive and non-hypertensive individuals.
METHODS
Twelve hypertensives and nine non-hypertensives were monitored during a 36-hour period using a repeated-measures panel study design. Personal exposure to PM2.5 was assessed using a real-time continuous monitor. Spot urine samples collected at 12-hour intervals were analyzed for 8-OHdG.
RESULTS
Exposure to PM2.5 was associated with a decrease in 8-OHdG in hypertensives compared with an increase in non-hypertensives, after adjusting for age, gender, smoking status, and time of day.
CONCLUSIONS
The results suggest modification of the association between PM2.5 exposure and urinary 8-OHdG by hypertension status. Antioxidant activity present in antihypertensive medications may play a role or PM2.5 exposure may reduce the capacity to repair DNA damage in hypertensives. These results should be confirmed with further investigation.
摘要
目的
研究高血压患者和非高血压患者中，颗粒物（PM2.5）与尿 8-羟基-2'-脱氧鸟苷（8-OHdG）之间的关联。
方法
采用重复测量面板研究设计，对 12 名高血压患者和 9 名非高血压患者进行 36 小时监测。使用实时连续监测仪评估个体 PM2.5 暴露情况。每隔 12 小时采集一次尿样，分析 8-OHdG。
结果
调整年龄、性别、吸烟状况和时间因素后，与非高血压患者相比，PM2.5 暴露与高血压患者 8-OHdG 降低有关。
结论
这些结果表明，高血压状态可能会改变 PM2.5 暴露与尿 8-OHdG 之间的关联。降压药物中存在的抗氧化活性可能发挥作用，或者 PM2.5 暴露可能会降低高血压患者修复 DNA 损伤的能力。需要进一步研究来证实这些结果。
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