Saalmüller A, Hirt W, Reddehase M J
Federal Research Centre for Virus Diseases of Animals, Tübingen.
Eur J Immunol. 1990 Oct;20(10):2343-6. doi: 10.1002/eji.1830201026.
Three types of T cell receptors (TcR) gamma/delta were identified in swine, all of which are disulfide-bonded cell surface heterodimers. The first, a 38/40-kDa molecule, is related to the TcR gamma/delta of sheep and cattle, and defines in swine a subset of CD4-CD8- T lymphocytes that is enriched in the circulating T lymphocyte pool. The other two receptors are private to swine. The second, a 37/40-kDa molecule, is expressed by the major subset of CD2-CD4-CD8- T lymphocytes that is neither enriched in nor excluded from lymphoid tissue. By contrast, the third type of TcR gamma/delta, a 40/46-kDa molecule, is found on CD2+CD4-CD8- T lymphocytes accumulating in lymphoid tissue. Thus, TcR gamma/delta T lymphocyte subsets differing in homing propensity are typified by the expression of distinct molecular forms of the TcR gamma/delta.
在猪中鉴定出三种类型的T细胞受体（TcR）γ/δ，它们均为通过二硫键连接的细胞表面异二聚体。第一种是38/40 kDa分子，与绵羊和牛的TcRγ/δ相关，并在猪中定义了一个CD4-CD8-T淋巴细胞亚群，该亚群在循环T淋巴细胞库中富集。另外两种受体是猪特有的。第二种是37/40 kDa分子，由CD2-CD4-CD8-T淋巴细胞的主要亚群表达，该亚群在淋巴组织中既不富集也不排除。相比之下，第三种类型的TcRγ/δ，即40/46 kDa分子，存在于在淋巴组织中积累的CD2+CD4-CD8-T淋巴细胞上。因此，归巢倾向不同的TcRγ/δT淋巴细胞亚群以TcRγ/δ不同分子形式的表达为特征。
