Department of Animal Science, University of Manitoba, Winnipeg, Manitoba, R3T2N2, Canada.
Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan international joint laboratory of Animal Intestinal Ecology and Health, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.
Sci China Life Sci. 2023 Sep;66(9):1994-2005. doi: 10.1007/s11427-022-2339-0. Epub 2023 Jun 6.
With gradual ban on the use of antibiotics, the deficiency and excessive use of trace elements in intestinal health is gaining attention. In mammals, trace elements are essential for the development of the immune system, specifically T-cell proliferation, and differentiation. However, there remain significant gaps in our understanding of the effects of certain trace elements on T-cell immune phenotypes and functions in pigs. In this review, we summarize the specificity, development, subpopulations, and responses to pathogens of porcine T cells and the effects of functional trace elements (e.g., iron, copper, zinc, and selenium) on intestinal T-cell immunity during early-life health in pigs. Furthermore, we discuss the current trends of research on the crosstalk mechanisms between trace elements and T-cell immunity. The present review expands our knowledge of the association between trace elements and T-cell immunity and provides an opportunity to utilize the metabolism of trace elements as a target to treat various diseases.
随着抗生素的逐步禁用，肠道健康中微量元素的缺乏和过量使用引起了人们的关注。在哺乳动物中，微量元素对于免疫系统的发育至关重要，特别是 T 细胞的增殖和分化。然而，我们对于某些微量元素对猪 T 细胞免疫表型和功能的影响的理解仍然存在很大的差距。在这篇综述中，我们总结了猪 T 细胞的特异性、发育、亚群以及对病原体的反应，以及功能性微量元素（如铁、铜、锌和硒）对仔猪早期生命健康期间肠道 T 细胞免疫的影响。此外，我们还讨论了微量元素与 T 细胞免疫之间相互作用机制的研究现状。本综述扩展了我们对微量元素与 T 细胞免疫之间关联的认识，并为利用微量元素代谢作为治疗各种疾病的靶点提供了机会。
