Hirt W, Saalmüller A, Reddehase M J
Federal Research Centre for Virus Diseases of Animals, Tübingen, FRG.
Eur J Immunol. 1990 Feb;20(2):265-9. doi: 10.1002/eji.1830200206.
The species swine provides the only example for CD2+ and CD2- subsets of Ig-CD4-CD8- lymphocytes with the propensity for homing to lymphoid tissue (Saalmüller et al., Eur. J. Immunol. 1989. 19: 2011). That the CD2-CD4-CD8- lymphocytes are bare of marker molecules that typify T lymphocytes raised the question of whether or not this cell type is descended from the T lymphocyte differentiation lineage. It is documented that expression of a phylogenetically conserved external epitope of T cell receptor gamma/delta subdivides porcine CD2- lymphocytes into an epitope 86D+ minor and an 86D- major subset. Expression of distinct forms of the T cell receptor gamma/delta, disulfide-bonded N-glycosylated surface heterodimers of under reducing conditions 38/40 and 37/40 kDa, respectively, hallmarks the CD2-86D+ and CD2-86D- subsets both as T lymphocytes.
猪这个物种为具有归巢至淋巴组织倾向的Ig-CD4-CD8-淋巴细胞的CD2+和CD2-亚群提供了唯一的例子（萨尔米勒等人，《欧洲免疫学杂志》，1989年。19: 2011）。CD2-CD4-CD8-淋巴细胞缺乏典型T淋巴细胞的标记分子，这就引发了一个问题，即这种细胞类型是否源自T淋巴细胞分化谱系。有文献记载，T细胞受体γ/δ的一个系统发育保守外部表位的表达将猪CD2-淋巴细胞细分为表位86D+的小亚群和86D-的大亚群。T细胞受体γ/δ的不同形式，即在还原条件下分别为38/40 kDa和37/40 kDa的二硫键连接的N-糖基化表面异二聚体的表达，标志着CD2-86D+和CD2-86D-亚群均为T淋巴细胞。
