Department of Anatomy, Akita University Graduate School of Medicine, 1-1-1, Hondo, Akita, 010-8543, Japan.
Histochem Cell Biol. 2009 Dec;132(6):577-84. doi: 10.1007/s00418-009-0638-5. Epub 2009 Sep 29.
Fatty acid binding protein of epidermal type (E-FABP) was expressed/localized in most, if not all, populations of the dendritic cells in the subepithelial domes, follicles and interfollicular regions of Peyer's patches and presumptive macrophages in their germinal centers, and all M cells in the follicle-associated epithelium of mouse intestine. The immunoreactivity in both of the cell populations makes it easy to recognize the accumulation of DCs in the subepithelial domes in close proximity to the base of M cells, which is essential for luminal antigens to be transported to Peyer's patches. E-FABP may play some important roles in the mucosal immune reaction through Peyer's patches and associated structures.
表皮型脂肪酸结合蛋白（E-FABP）表达/定位于派尔集合淋巴结黏膜固有层穹隆、滤泡和滤泡间区以及生发中心的假定巨噬细胞中大多数（如果不是全部）树突状细胞，以及小鼠肠腔的滤泡相关上皮中的所有 M 细胞。这两种细胞群的免疫反应使得很容易识别出在 M 细胞基底附近的黏膜固有层穹隆中 DC 的聚集，这对于将腔抗原转运到派尔集合淋巴结是必不可少的。E-FABP 可能通过派尔集合淋巴结和相关结构在黏膜免疫反应中发挥一些重要作用。
