Department of Urology, Alexandrov's University Hospital, Medical University, G. Sofiisky Blvd 1, 1431, Sofia, Bulgaria.
Amino Acids. 2010 May;38(5):1277-82. doi: 10.1007/s00726-009-0359-z. Epub 2009 Sep 29.
Plasma levels and urinary amino acid excretions were estimated by high-performance liquid chromatography in 15 control subjects and 36 stone formers (SFs) classified according to the stone type: (1) 22 cases with calcium oxalate stones; (2) four cases with pure uric acid stones; (3) 10 cases with magnesium-ammonium phosphate stones, either pure or mixed with apatite. Some types of stones (namely oxalate and uric acid calculi) are mainly formed as a result of a metabolic deficiency that may affect the amino acid metabolism, and thus may be reflected in the urinary amino acid pattern. Data demonstrated clearly that there is a general tendency towards decreased amino acid excretions in all SFs with all types of stones. As a whole, one can observe a higher percentage of patients with calcium oxalate and phosphate calculosis, who have low urine excretions of amino acids; about 50% are the SFs with lower urine excretion of serine, glycine, taurine and i-leucine; the high percentage of patients with CaOX calculi shows lower urine excretions of tyrosine and ornithine.
15 名对照受试者和 36 名结石形成者（SFs）的血浆水平和尿氨基酸排泄量通过高效液相色谱法进行了估计，这些 SFs 根据结石类型进行了分类：（1）22 例草酸钙结石；（2）4 例纯尿酸结石；（3）10 例镁-铵磷酸盐结石，无论是纯的还是与磷灰石混合的。某些类型的结石（即草酸钙和尿酸结石）主要是由于代谢缺陷形成的，这可能会影响氨基酸代谢，因此可能会反映在尿氨基酸模式中。数据清楚地表明，所有类型结石的所有 SFs 均存在氨基酸排泄普遍减少的趋势。总的来说，大约有 50%的草酸钙和磷酸盐结石患者的尿氨基酸排泄量较低；大约 50%的 SFs 的丝氨酸、甘氨酸、牛磺酸和异亮氨酸尿排泄量较低；高百分比的 CaOX 结石患者的酪氨酸和鸟氨酸尿排泄量较低。
