Planta Med. 2010 Mar;76(4):362-4. doi: 10.1055/s-0029-1186160. Epub 2009 Sep 28.
Mulberroside A, a major stilbene constituent of MORUS ALBA L. (Moraceae), displays significant antitussive and antiasthmatic effects in animals. As part of our ongoing research on its biotransformation in rats, mulberroside A was orally administered to rats, and the metabolites in the gastrointestinal contents and feces were investigated. Three major metabolites were isolated from the feces of rats and identified as oxyresveratrol-2- O- beta- D-glucopyranoside ( 1), oxyresveratrol-3'- O- beta- D-glucopyranoside ( 2), and oxyresveratrol ( 3) on the basis of chemical and spectroscopic evidence. The three metabolites were also detected in the small intestinal contents of rats following oral administration of mulberroside A. These findings suggest that mulberroside A is metabolized prior to absorption into the body.
桑根酮 A，桑科植物桑（Moraceae）的主要白藜芦醇成分，在动物中具有显著的镇咳和平喘作用。作为我们对其在大鼠体内生物转化的持续研究的一部分，桑根酮 A 被口服给予大鼠，并研究了胃肠道内容物和粪便中的代谢物。从大鼠粪便中分离出三种主要代谢物，并根据化学和光谱证据将其鉴定为氧白藜芦醇-2-O-β-D-吡喃葡萄糖苷（1）、氧白藜芦醇-3'-O-β-D-吡喃葡萄糖苷（2）和氧白藜芦醇（3）。口服桑根酮 A 后，这些代谢物也在大鼠的小肠内容物中被检测到。这些发现表明，桑根酮 A 在被吸收到体内之前就被代谢了。
