从桑属（Mulberry）植物中筛选出的选择性和高效黑色素生成抑制剂的结构-活性关系研究。

Screening and Structure-Activity Relationship for Selective and Potent Anti-Melanogenesis Agents Derived from Species of Mulberry (Genus ).

机构信息

Department of Pharmacology and Toxicology, Faculty of Medicine, University of Warmia and Mazury, Warszawska 30 Street, 10-082 Olsztyn, Poland.

Department of Toxicology and Bromatology, Faculty of Pharmacy, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń, A. Jurasza 2 Street, 85-089 Bydgoszcz, Poland.

出版信息

Molecules. 2022 Dec 17;27(24):9011. doi: 10.3390/molecules27249011.

DOI:10.3390/molecules27249011

PMID:36558142

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9783946/

Abstract

Tyrosinase is a multifunctional, copper-containing and rate-limiting oxidase that catalyses crucial steps in the melanogenesis pathway and is responsible for skin-pigmentation abnormalities in mammals. Numerous tyrosinase inhibitors derived from natural and synthetic sources have been identified as an objective for the development of anti-melanogenesis agents. However, due to side effects and lack of expected efficiency, only a small percentage of them are used for medical and cosmetic purposes. This critical review focuses on searching for novel active substances and recently discovered plant-derived anti-tyrosinase inhibitors from the genus ( family). A detailed analysis of their structure-activity relationships is discussed. The information contained in this article is crucial for the cosmetics and medical industries, in order to show new directions for the effective search for natural anti-melanogenesis products (with satisfactory efficiency and safety) to treat and cure hyperpigmentation.

摘要

酪氨酸酶是一种多功能含铜的限速氧化酶，它催化黑素生成途径中的关键步骤，负责哺乳动物的皮肤色素异常。已经从天然和合成来源中鉴定出许多酪氨酸酶抑制剂，作为开发抗黑色素生成剂的目标。然而，由于副作用和缺乏预期的效率，只有一小部分被用于医学和美容目的。本综述重点介绍了从属（科）中寻找新型活性物质和最近发现的植物源性抗酪氨酸酶抑制剂。讨论了它们的结构-活性关系的详细分析。本文中的信息对于化妆品和医疗行业至关重要，以便为有效寻找具有令人满意的效率和安全性的天然抗黑色素生成产品（以治疗和治愈色素沉着过度）指明新的方向。