Caruana Joseph A, Anain Paul M, Pham Dang Tuan
Department of Surgery, Sisters of Charity Hospital and the State University of New York at Buffalo, Buffalo, NY 14221, USA.
Surgery. 2009 Oct;146(4):678-83; discussion 683-5. doi: 10.1016/j.surg.2009.07.011.
Pulmonary embolism (PE) is a leading cause of death after roux-en-Y gastric bypass (RYGB); therefore, current recommendations for prophylaxis may be inadequate.
We reviewed our first 1,341 patients (controls) who underwent RYGB and weighted factors that may have contributed to PE to arrive at a pulmonary embolism risk score (PERS). We postulated that more aggressive prophylaxis in higher risk patients might have reduced the incidence of PE. We tested our hypothesis by basing prophylaxis on the PERS in 1,652 subsequent RYGB patients (study group). Standard risk patients (PERS <4) were ambulated 2 hours after surgery, had application of intermittent compression devices, and received subcutaneous low-dose, unfractionated heparin (LDUH). Intermediate risk patients (PERS = 4) received standard prophylaxis and 3 weeks of postdischarge LDUH. High-risk patients (PERS >4) had postdischarge LDUH and a preoperative vena cava filter.
The 0.36% incidence of PE (6 patients) in the study group was significantly lower (P <.05) than the 1% incidence (13 patients) in the controls. Three of 189 men in the control group died of PE, whereas there were no deaths from PE in 271 men in the study group (P <.05).
The PERS may be an appropriate scoring system for determining preoperatively the level of risk for postoperative PE in RYGB patients. Basing prophylaxis on the level of risk reduces the incidence and mortality of PE and consumes resources judiciously.
肺栓塞(PE)是胃旁路手术(RYGB)后导致死亡的主要原因之一;因此,目前的预防建议可能并不充分。
我们回顾了首批1341例行RYGB手术的患者(对照组),对可能导致PE的因素进行加权,得出肺栓塞风险评分(PERS)。我们推测,对高风险患者采取更积极的预防措施可能会降低PE的发生率。我们通过对随后1652例行RYGB手术的患者(研究组)根据PERS进行预防来检验我们的假设。标准风险患者(PERS<4)术后2小时开始活动,使用间歇性压迫装置,并皮下注射低剂量普通肝素(LDUH)。中度风险患者(PERS=4)接受标准预防措施及出院后3周的LDUH治疗。高风险患者(PERS>4)出院后接受LDUH治疗并在术前植入腔静脉滤器。
研究组PE的发生率为0.36%(6例患者),显著低于对照组的1%(13例患者)(P<.05)。对照组189名男性中有3例死于PE,而研究组271名男性中无PE死亡病例(P<.05)。
PERS可能是一种合适的评分系统,用于术前确定RYGB患者术后发生PE的风险水平。根据风险水平进行预防可降低PE的发生率和死亡率,并合理利用资源。