Ferrari Paolo
Department of Nephrology, Fremantle Hospital, University of Western Australia, Perth, Australia.
Kidney Int. 2009 Oct;76(8):811-2. doi: 10.1038/ki.2009.282.
In patients on hemodialysis, Farese et al. report that inhibition of the enzyme 11beta-hydroxysteroid dehydrogenase type 2 by glycyrrhetinic acid, the active compound of licorice, reduces serum potassium concentration and the frequency of hyperkalemia, possibly by enhancing intestinal potassium loss. This finding could be an important tool to maintain predialysis [K(+)] within safe limits in some dialysis patients at risk of hyperkalemic arrhythmias.
法雷斯等人报告称，在接受血液透析的患者中，甘草的活性成分甘草次酸对2型11β-羟基类固醇脱氢酶的抑制作用可能通过增强肠道排钾，降低了血清钾浓度和高钾血症的发生率。这一发现可能是将部分有高钾性心律失常风险的透析患者透析前血钾水平维持在安全范围内的一项重要手段。
