Nowak Debra A, Snyder Denise C, Brown Ann J, Demark-Wahnefried Wendy
Duke University School of Nursing, Box 3322 Duke University Medical Center, Durham, NC 27710.
Curr Top Nutraceutical Res. 2007;5(4):177-181.
Flaxseed is a rich source of lignan and has been shown to reduce androgen levels in men with prostate cancer. Polycystic ovarian syndrome (PCOS), a common endocrine disorder among women in their reproductive years, also is associated with high levels of androgens and is frequently accompanied by hirsutism, amenorrhea and obesity. This clinical case study describes the impact of flaxseed supplementation (30 g/day) on hormonal levels in a 31-year old woman with PCOS. During a four month period, the patient consumed 83% of the flaxseed dose. Heights, weights, and fasting blood samples taken at baseline and 4-month follow-up indicated the following values: BMI (36.0 vs. 35.7m/kg(2)); insulin (5.1 vs. 7.0 uIU/ml); total serum testosterone (150 ng/dl vs. 45 ng/dl); free serum testosterone (4.7 ng/dl vs. 0.5 ng/dl); and % free testosterone (3.1% vs. 1.1%). The patient also reported a decrease in hirsutism at the completion of the study period. The clinically-significant decrease in androgen levels with a concomitant reduction in hirsutism reported in this case study demonstrates a need for further research of flaxseed supplementation on hormonal levels and clinical symptoms of PCOS.
亚麻籽是木脂素的丰富来源，并且已被证明可降低前列腺癌男性的雄激素水平。多囊卵巢综合征（PCOS）是育龄期女性常见的内分泌紊乱疾病，也与高水平的雄激素有关，常伴有多毛症、闭经和肥胖。本临床病例研究描述了补充亚麻籽（30克/天）对一名31岁PCOS女性激素水平的影响。在四个月的时间里，患者摄入了83%的亚麻籽剂量。在基线和4个月随访时测量的身高、体重和空腹血样显示了以下数值：体重指数（36.0对35.7m/kg²）；胰岛素（5.1对7.0 uIU/ml）；总血清睾酮（150 ng/dl对45 ng/dl）；游离血清睾酮（4.7 ng/dl对0.5 ng/dl）；以及游离睾酮百分比（3.1%对1.1%）。患者还报告在研究期结束时多毛症有所减轻。本病例研究报告的雄激素水平显著下降以及多毛症随之减轻，表明需要进一步研究补充亚麻籽对PCOS激素水平和临床症状的影响。
