Service de Neurophysiologie Clinique, Unité des troubles de la veille et du sommeil, EA 2683, IFR 114, Hôpital Roger Salengro, CHRU de Lille, Lille cedex, 59037, France.
J Neurol. 2010 Mar;257(3):383-91. doi: 10.1007/s00415-009-5328-7. Epub 2009 Sep 30.
In idiopathic rapid eye movement sleep behaviour disorder (RBD), an association with visuoperceptive disorders has been described. However, such an association has not been clearly established in RBD secondary to Parkinson's disease (PD). We compared visuoperceptive function in four groups of non-demented patients (parkinsonian patients with or without RBD, patients with idiopathic RBD and control participants) via a procedure enabling the analysis of the various components of visual information processing and in order to answer the following question: is RBD associated with visuoperceptive and/or attentional disorders in PD and, if so, where is the dysfunction located along the visual pathway? Sensorial aspects of visual information were evaluated using a contrast sensitivity test, perceptual aspects were assessed using a contour-based object identification test and visual attention was measured in an attentional capture paradigm. The diagnosis of RBD was confirmed by polysomnography. We observed a higher object identification threshold (OIT) (1) in PD patients with RBD compared with PD patients without RBD and with controls and (2) in idiopathic RBD patients compared with controls. There were no significant OIT differences between PD patients with RBD and idiopathic RBD patients or between PD patients without RBD and controls. We did not find any significant inter-group differences in any of the other visuoperceptive tests. RBD, idiopathic or secondary to PD, is associated with perceptual closure dysfunction. Our results suggest that this perceptual dysfunction is specifically associated with RBD and may be related to a non-dopaminergic impairment.
在特发性快速眼动睡眠行为障碍（RBD）中，已经描述了与视知觉障碍的关联。然而，在帕金森病（PD）继发的 RBD 中，这种关联尚未得到明确确立。我们通过一种能够分析视觉信息处理各个组成部分的程序，比较了四组非痴呆患者（有或没有 RBD 的帕金森病患者、特发性 RBD 患者和对照组参与者）的视知觉功能，以回答以下问题：RBD 是否与 PD 中的视知觉和/或注意力障碍有关，如果是，功能障碍位于视觉通路的何处？我们使用对比敏感度测试评估了视觉信息的感觉方面，使用基于轮廓的物体识别测试评估了知觉方面，并且在注意力捕获范式中测量了视觉注意力。通过多导睡眠图确认 RBD 的诊断。我们观察到 RBD 组的 PD 患者的物体识别阈值（OIT）（1）高于无 RBD 的 PD 患者和对照组，（2）高于特发性 RBD 患者和对照组。有 RBD 的 PD 患者和特发性 RBD 患者之间或无 RBD 的 PD 患者和对照组之间的 OIT 差异没有统计学意义。我们在任何其他视知觉测试中都没有发现任何组间差异。RBD，无论是特发性还是继发于 PD，都与知觉闭合功能障碍有关。我们的结果表明，这种知觉功能障碍与 RBD 特异性相关，可能与非多巴胺能损伤有关。
