Gagnon Jean-François, Postuma Ronald B, Mazza Stéphanie, Doyon Julien, Montplaisir Jacques
Centre d'étude du Sommeil et des Rythmes Biologiques, Hôpital du Sacré-Coeur de Montréal, Québec, Canada.
Lancet Neurol. 2006 May;5(5):424-32. doi: 10.1016/S1474-4422(06)70441-0.
Rapid-eye-movement (REM) sleep behaviour disorder (RBD) is characterised by loss of muscular atonia and prominent motor behaviours during REM sleep. RBD can cause sleep disruption and severe injuries for the patient or bed partner. The disorder is strongly associated with neurodegenerative diseases, such as multiple-system atrophy, Parkinson's disease, dementia with Lewy bodies, and progressive supranuclear palsy. In many cases, the symptoms of RBD precede other symptoms of these neurodegenerative disorders by several years. Furthermore, several recent studies have shown that RBD is associated with abnormalities of electroencephalographic activity, cerebral blood flow, and cognitive, perceptual, and autonomic functions. RBD might be a stage in the development of neurodegenerative disorders and increased awareness of this could lead to substantial advances in knowledge of mechanisms, diagnosis, and treatment of neurodegenerative disorders.
快速眼动（REM）睡眠行为障碍（RBD）的特征是在快速眼动睡眠期间肌肉张力缺失和出现显著的运动行为。RBD可导致患者或同床伴侣睡眠中断及严重受伤。该障碍与神经退行性疾病密切相关，如多系统萎缩、帕金森病、路易体痴呆和进行性核上性麻痹。在许多情况下，RBD的症状比这些神经退行性疾病的其他症状早出现数年。此外，最近的几项研究表明，RBD与脑电图活动、脑血流量以及认知、感知和自主神经功能异常有关。RBD可能是神经退行性疾病发展过程中的一个阶段，提高对此的认识可能会在神经退行性疾病的机制、诊断和治疗知识方面取得重大进展。
