早期卵裂对胚胎发育潜能及 IVF/ICSI 结局的影响。
The influence of early cleavage on embryo developmental potential and IVF/ICSI outcome.
机构信息
IVF Centre, International Peace Maternity & Child Health Hospital, Jiao Tong University Medical School, Shanghai, China.
出版信息
J Assist Reprod Genet. 2009 Aug;26(8):437-41. doi: 10.1007/s10815-009-9342-6. Epub 2009 Sep 30.
Abstract
PURPOSE
To observe whether early cleavage can be a predictor of embryo developmental potential, pregnancy and implantation rates.
METHODS
A total of 9,544 embryos in 1,095 in vitro fertilization or intracytoplasmic sperm injection cycles were observed with regard to the appearance of early cleavage at 25-29 h post-insemination.
RESULTS
A significantly higher proportion of excellent quality embryos were observed in the early cleavage group compared to the late cleavage group (52.5 versus 28.9%, P < 0.01). In the early cleavage group there was also a higher rate of pregnancy per transfer compared with the late cleavage group (38.7 versus 26.3%, P < 0.01). In addition, we found that transfer of only one early cleavage embryo resulted in a high pregnancy rate (38.5%) and a low multiple pregnancy rate (18.0%).
CONCLUSION
Early cleavage is a strong indicator of embryo quality, and may be used as an additional criterion in the selection of embryos for transfer to increase pregnancy rate and reduce multiple pregnancy rate.
摘要
目的
观察早期卵裂是否可作为胚胎发育潜能、妊娠率和种植率的预测指标。
方法
对 1095 个体外受精或卵胞浆内单精子注射周期的 9544 个胚胎，观察受精后 25-29 小时早期卵裂的外观。
结果
与晚期卵裂组相比，早期卵裂组优质胚胎的比例明显更高（52.5%比 28.9%，P<0.01）。早期卵裂组的每周期妊娠率也高于晚期卵裂组（38.7%比 26.3%，P<0.01）。此外，我们发现仅移植一个早期卵裂胚胎即可获得较高的妊娠率（38.5%）和较低的多胎妊娠率（18.0%）。
结论
早期卵裂是胚胎质量的一个有力指标，可作为选择胚胎移植的附加标准，以提高妊娠率，降低多胎妊娠率。
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