Pedersen A, Klausen B, Hougen H P, Ryder L, Winther K
Department of Dentistry, University Hospital (Rigshospitalet), Copenhagen, Denmark.
J Oral Pathol Med. 1990 Sep;19(8):376-80. doi: 10.1111/j.1600-0714.1990.tb00863.x.
LongoVital (LV) (DK. Reg. No. 5178/75) is a herbal based tablet enriched with recommended doses of vitamins. Peripheral lymphocyte subsets: T-helper/CD4 (OKT4+) and T-suppressor/cytotoxic/CD8 (OKT8+) were studied quantitatively in 31 otherwise healthy patients with minor recurrent aphthous ulceration (RAU) during 6 months' daily LV intake in a double-blind, randomized, crossover 1-year study. Fourteen had had LV during the first 6 months (GrA) and 17 LV during the latter 6 months (GrB). OKT4+ percentages increased significantly during the LV period in both groups (P less than 0.05). OKT8+ percentages increased in both groups, however, only significantly in GrA (P less than 0.05). It is concluded that LV acts as an immunostimulator in patients with RAU and that the increase in T-lymphocyte subsets may account for the previously reported benefit of LV in RAU prevention.
朗格活力素（LV）（丹麦注册号：5178/75）是一种富含推荐剂量维生素的草本片剂。在一项为期1年的双盲、随机、交叉研究中，对31名患有轻度复发性阿弗他溃疡（RAU）的健康患者进行了为期6个月的每日LV摄入研究，定量研究外周血淋巴细胞亚群：辅助性T细胞/CD4（OKT4 +）和抑制性/细胞毒性T细胞/CD8（OKT8 +）。14名患者在头6个月服用LV（A组），17名患者在随后6个月服用LV（B组）。两组在服用LV期间OKT4 +百分比均显著增加（P < 0.05）。两组OKT8 +百分比均增加，但仅A组显著增加（P < 0.05）。结论是，LV对RAU患者起免疫刺激作用，T淋巴细胞亚群的增加可能解释了先前报道的LV在预防RAU方面的益处。
