Momiji Hiroshi, Monk Nicholas A M
Department of Biomedical Science, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom.
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Aug;80(2 Pt 1):021930. doi: 10.1103/PhysRevE.80.021930. Epub 2009 Aug 24.
Lateral inhibition resulting from a double-negative feedback loop underlies the assignment of different fates to cells in many developmental processes. Previous studies have shown that the presence of time delays in models of lateral inhibition can result in significant oscillatory transients before patterned steady states are reached. We study the impact of local feedback loops in a model of lateral inhibition based on the Notch signaling pathway, elucidating the roles of intracellular and intercellular delays in controlling the overall system behavior. The model exhibits both in-phase and out-of-phase oscillatory modes and oscillation death. Interactions between oscillatory modes can generate complex behaviors such as intermittent oscillations. Our results provide a framework for exploring the recent observation of transient Notch-pathway oscillations during fate assignment in vertebrate neurogenesis.
由双负反馈回路产生的侧向抑制是许多发育过程中细胞命运分配的基础。先前的研究表明，侧向抑制模型中时间延迟的存在会导致在达到模式化稳态之前出现显著的振荡瞬态。我们研究了基于Notch信号通路的侧向抑制模型中局部反馈回路的影响，阐明了细胞内和细胞间延迟在控制整个系统行为中的作用。该模型表现出同相和异相振荡模式以及振荡死亡。振荡模式之间的相互作用可以产生复杂的行为，如间歇性振荡。我们的结果为探索脊椎动物神经发生过程中命运分配期间Notch通路瞬态振荡的最新观察结果提供了一个框架。
