Hatcher Simon, Sharon Cynthia, Coggan Carol
Department of Psychological Medicine, Faculty of Medical and Health Sciences, University of Auckland, Auckland.
Suicide Life Threat Behav. 2009 Aug;39(4):396-407. doi: 10.1521/suli.2009.39.4.396.
There is a lack of evidence about what is the best treatment for people who present to hospital after self harm. Most treatment trials have been small and involved unrepresentative groups of patients which result in inconclusive findings. Here we note some of the characteristics of attempted suicide which make it a difficult subject to study. We describe the problems of doing randomized controlled trials in attempted suicide and outline the advantages and difficulties of randomized controlled trials, Zelen designs, patient preference designs, and cluster randomized trials in attempted suicide intervention trials. Researchers and consumers should consider other research designs when asking what is effective after self harm.
对于自残后入院的患者，目前尚无证据表明哪种治疗方法最佳。大多数治疗试验规模较小，且涉及的患者群体缺乏代表性，导致研究结果尚无定论。在此，我们指出了一些自杀未遂的特征，这些特征使其成为一个难以研究的课题。我们描述了在自杀未遂研究中进行随机对照试验的问题，并概述了自杀未遂干预试验中随机对照试验、泽伦设计、患者偏好设计和整群随机试验的优缺点。在探讨自残后何种治疗方法有效时，研究人员和患者应考虑其他研究设计。
