Antinori S, Corbellino M, Necchi A, Corradini P, Vismara C, Montefusco V, Gianni A M
Department of Clinical Sciences, Section of Infectious Diseases and Immunopathology, Università degli Studi di Milano, Milan, Italy.
Transpl Infect Dis. 2010 Feb;12(1):64-8. doi: 10.1111/j.1399-3062.2009.00460.x. Epub 2009 Sep 30.
We describe an autologous stem cell transplant recipient who developed immune reconstitution inflammatory syndrome (IRIS) associated with Aspergillus terreus invasive pulmonary infection after recovery from neutropenia. Clinical and radiological worsening of pulmonary invasive aspergillosis coincident with a robust decline of serum galactomannan values and rising neutrophil counts should be interpreted as IRIS and should not require changes to antifungal therapy.
我们描述了一名自体干细胞移植受者，该患者在从中性粒细胞减少症恢复后，发生了与土曲霉侵袭性肺部感染相关的免疫重建炎症综合征（IRIS）。侵袭性肺曲霉病的临床和影像学恶化与血清半乳甘露聚糖值的显著下降及中性粒细胞计数升高同时出现，应被解释为IRIS，且无需改变抗真菌治疗。
