Lehrnbecher Thomas, Becker Martina, Schwabe Dirk, Köhl Ulrike, Kriener Susanne, Hunfeld Klaus-Peter, Schmidt Helga, Beyer Peter, Klingebiel Thomas, Bader Peter, Sörensen Jan
Department of Pediatric Hematology, Johann Wolfgang University of Frankfurt, Germany.
Pediatr Infect Dis J. 2006 May;25(5):465-6. doi: 10.1097/01.inf.0000217475.83393.f6.
Primary invasive aspergillosis of the gut is a rare event and is associated with high mortality. We report for the first time on a patient who had isolated aspergillosis of the small bowel after autologous stem cell transplantation. Diagnosis of invasive aspergillosis of the gut was based on abdominal pain, galactomannan antigenemia and isolation of Aspergillus fumigatus from the stool and was later confirmed by pathohistologic examination. No other site of invasive aspergillosis was evident. The patient was successfully treated with early surgery and combination antifungal therapy.
原发性肠道侵袭性曲霉病是一种罕见的疾病，且死亡率很高。我们首次报告了一名自体干细胞移植后发生孤立性小肠曲霉病的患者。肠道侵袭性曲霉病的诊断基于腹痛、半乳甘露聚糖抗原血症以及从粪便中分离出烟曲霉，随后经病理组织学检查得以证实。未发现其他侵袭性曲霉病病灶。该患者通过早期手术和联合抗真菌治疗获得了成功治愈。
