Ladak Adil, Tredget Edward E
Department of Surgery, University of Alberta, Edmonton, Canada.
Clin Plast Surg. 2009 Oct;36(4):661-74. doi: 10.1016/j.cps.2009.05.014.
Fibroproliferative disorders (FPDs) are common and serious disorders. Hypertrophic scar (HSc) and keloids represent the dermal equivalents of FPD and impose lower mortality but great morbidity. This article reviews current knowledge in the pathophysiology and molecular and cellular characteristics of postburn HSc. Additionally, current treatment modalities and future treatment options based on advancements in the understanding of the pathophysiology of HSc are discussed.
纤维增生性疾病（FPDs）是常见且严重的疾病。增生性瘢痕（HSc）和瘢痕疙瘩是FPD的皮肤等效物，死亡率较低但发病率很高。本文综述了烧伤后增生性瘢痕的病理生理学以及分子和细胞特征方面的现有知识。此外，还讨论了基于对增生性瘢痕病理生理学认识的进展而形成的当前治疗方式和未来治疗选择。
