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KRAS and TP53 mutations in colorectal carcinoma.

作者信息

Al-Kuraya Khawla S

出版信息

Saudi J Gastroenterol. 2009 Oct-Dec;15(4):217-9. doi: 10.4103/1319-3767.56087.

DOI:10.4103/1319-3767.56087
PMID:19794264
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2981835/
Abstract
摘要

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KRAS and TP53 mutations in colorectal carcinoma.结直肠癌中的KRAS和TP53突变
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KRAS mutations in primary and metastatic colorectal cancer.原发性和转移性结直肠癌中的KRAS突变
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TP53 and let-7a micro-RNA regulate K-Ras activity in HCT116 colorectal cancer cells.TP53 和 let-7a 微 RNA 调节 HCT116 结直肠癌细胞中的 K-Ras 活性。
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本文引用的文献

1
Molecular gate keepers succumb to gene aberrations in colorectal cancer in Kashmiri population, revealing a high incidence area.在克什米尔人群的结直肠癌中，分子门控因子因基因异常而失活，揭示了一个高发地区。
Saudi J Gastroenterol. 2009 Oct-Dec;15(4):244-52. doi: 10.4103/1319-3767.56102.
2
PIK3CA mutations in colorectal cancer are associated with clinical resistance to EGFR-targeted monoclonal antibodies.结直肠癌中的PIK3CA突变与对表皮生长因子受体（EGFR）靶向单克隆抗体的临床耐药性相关。
Cancer Res. 2009 Mar 1;69(5):1851-7. doi: 10.1158/0008-5472.CAN-08-2466. Epub 2009 Feb 17.
3
Mutations in the RAS-MAPK, PI(3)K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers.在一项基于人群的结肠癌系列研究中，RAS-MAPK、PI(3)K（磷脂酰肌醇-3-羟基激酶）信号网络中的突变与较差的生存率相关。
Int J Cancer. 2008 May 15;122(10):2255-9. doi: 10.1002/ijc.23388.
4
Clinicopathological analysis of colorectal cancers with PIK3CA mutations in Middle Eastern population.中东人群中携带PIK3CA突变的结直肠癌的临床病理分析
Oncogene. 2008 Jun 5;27(25):3539-45. doi: 10.1038/sj.onc.1211013. Epub 2008 Jan 14.
5
Colorectal cancer: a multipathway disease.结直肠癌：一种多途径疾病。
Crit Rev Oncog. 2006 Dec;12(3-4):273-87. doi: 10.1615/critrevoncog.v12.i3-4.50.
6
HER2, TOP2A, CCND1, EGFR and C-MYC oncogene amplification in colorectal cancer.结直肠癌中HER2、TOP2A、CCND1、EGFR和C-MYC癌基因扩增
J Clin Pathol. 2007 Jul;60(7):768-72. doi: 10.1136/jcp.2006.038281. Epub 2006 Aug 1.
7
KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer.KRAS 突变状态可预测结直肠癌患者对西妥昔单抗治疗的反应。
Cancer Res. 2006 Apr 15;66(8):3992-5. doi: 10.1158/0008-5472.CAN-06-0191.
8
Beyond 5-fluorouracil: new horizons in systemic therapy for advanced colorectal cancer.超越5-氟尿嘧啶：晚期结直肠癌全身治疗的新视野
Expert Opin Investig Drugs. 2005 Jun;14(6):607-28. doi: 10.1517/13543784.14.6.607.
9
Bevacizumab in combination with fluorouracil and leucovorin: an active regimen for first-line metastatic colorectal cancer.贝伐单抗联合氟尿嘧啶和亚叶酸钙：一线转移性结直肠癌的有效治疗方案。
J Clin Oncol. 2005 May 20;23(15):3502-8. doi: 10.1200/JCO.2005.10.017.
10
p53 mutation profile of squamous cell carcinomas of the esophagus in Kashmir (India): a high-incidence area.印度克什米尔地区：一个食管癌高发地区食管鳞状细胞癌的p53突变谱
Int J Cancer. 2005 Aug 10;116(1):62-8. doi: 10.1002/ijc.21002.