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人肾肿瘤细胞系中对阿霉素的天然耐药性、增殖活性与P-糖蛋白170表达之间的相关性。

Correlations between natural resistance to doxorubicin, proliferative activity, and expression of P-glycoprotein 170 in human kidney tumor cell lines.

作者信息

Efferth T, Löhrke H, Volm M

机构信息

German Cancer Research Center, Institute of Experimental Pathology, Heidelberg.

出版信息

Urol Res. 1990;18(5):309-12. doi: 10.1007/BF00300777.

DOI:10.1007/BF00300777
PMID:1979457
Abstract

The natural resistance to doxorubicin of 15 human renal carcinoma cell lines was analyzed and compared to proliferative activity and expression of P-glycoprotein. We found a significant negative correlation between proliferative activity and natural resistance to doxorubicin, as well as between proliferative activity and the expression of P-glycoprotein. A positive correlation between resistance and expression of P-glycoprotein was found.

摘要

分析了15种人肾癌细胞系对阿霉素的天然耐药性，并将其与增殖活性和P-糖蛋白表达进行比较。我们发现增殖活性与对阿霉素的天然耐药性之间、增殖活性与P-糖蛋白表达之间均存在显著负相关。同时发现耐药性与P-糖蛋白表达之间呈正相关。

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Urol Res. 1990;18(5):309-12. doi: 10.1007/BF00300777.
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本文引用的文献

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Suppression of endogenous avidin-binding activity in tissues and its relevance to biotin-avidin detection systems.组织中内源性抗生物素蛋白结合活性的抑制及其与生物素-抗生物素蛋白检测系统的相关性。
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Intrinsic drug resistance in human kidney cancer is associated with expression of a human multidrug-resistance gene.人类肾癌中的内在耐药性与一种人类多药耐药基因的表达相关。
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Measurement of multidrug-resistance messenger RNA in urogenital cancers; elevated expression in renal cell carcinoma is associated with intrinsic drug resistance.泌尿生殖系统癌症中多药耐药信使核糖核酸的检测；肾细胞癌中表达升高与内在耐药性相关。
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Induced multidrug-resistance in murine sarcoma 180 cells grown in vitro and in vivo and associated changes in expression of multidrug-resistance DNA-sequences and membrane glycoproteins.
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