Phillips Jonathan E, Ji Lunan, Rivelli Maria A, Chapman Richard W, Corboz Michel R
Pulmonary and Peripheral Neurobiology, Schering-Plough Research Institute, Kenilworth, NJ 07033, USA.
Can J Vet Res. 2009 Jul;73(3):205-11.
Continuous isometric microfocal X-ray computed tomography (CT) scans were acquired from an AKR/J mouse, Brown-Norway rat, and Hartley guinea pig. The anatomy and volume of the paranasal sinus cavities were defined from 2-dimensional (2-D) and 3-dimensional (3-D) CT images. Realistic 3-D images were reconstructed and used to determine the anterior maxillary, posterior maxillary, and ethmoid sinus cavity airspace volumes (mouse: 0.6, 0.7, and 0.7 mm(3), rat: 8.6, 7.7, and 7.0 mm(3), guinea pig: 63.5, 46.6 mm(3), and no ethmoid cavity, respectively). The mouse paranasal sinus cavities are similar to the corresponding rat cavities, with a reduction in size, while the corresponding maxillary sinus cavities in the guinea pig are different in size, location, and architecture. Also, the ethmoid sinus cavity is connected by a common drainage pathway to the posterior maxillary sinus in mouse and rat while a similar ethmoid sinus was not present in the guinea pig. We conclude that paranasal sinus cavity airspace opacity (2-D) or volume (3-D) determined by micro-CT scanning may be used to conduct longitudinal studies on the patency of the maxillary sinus cavities of rodents. This represents a potentially useful endpoint for developing and testing drugs in a small animal model of sinusitis.
对一只AKR/J小鼠、一只棕色挪威大鼠和一只哈特利豚鼠进行了连续等距微焦点X射线计算机断层扫描（CT）。从二维（2-D）和三维（3-D）CT图像中确定了鼻窦腔的解剖结构和体积。重建了逼真的三维图像，并用于确定上颌前、上颌后和筛窦腔的气腔体积（小鼠分别为0.6、0.7和0.7立方毫米，大鼠分别为8.6、7.7和7.0立方毫米，豚鼠分别为63.5、46.6立方毫米，且豚鼠无筛窦腔）。小鼠的鼻窦腔与相应的大鼠鼻窦腔相似，但尺寸减小，而豚鼠相应的上颌窦腔在大小、位置和结构上有所不同。此外，小鼠和大鼠的筛窦腔通过一条共同的引流途径与上颌后窦相连，而豚鼠不存在类似的筛窦。我们得出结论，通过微CT扫描确定的鼻窦腔气腔不透明度（二维）或体积（三维）可用于对啮齿动物上颌窦腔通畅性进行纵向研究。这代表了在鼻窦炎小动物模型中开发和测试药物的一个潜在有用的终点。
