Division of Endoscopy, Hokkaido University Hospital, Sapporo 060-8468, Japan.
J Clin Biochem Nutr. 2009 Sep;45(2):248-53. doi: 10.3164/jcbn.09-24. Epub 2009 Aug 28.
Although low-dose aspirin is widely used, since it is a cheap and effective means of prevention of cardiovascular events, it can cause hemorrhagic gastrointestinal complications. The aim of this study was to evaluate the efficacy of rebamipide in preventing low-dose aspirin-induced gastric injury. A randomized, double-blind, placebo-controlled, crossover trial was performed in twenty healthy volunteers. Aspirin 81 mg was administered with placebo or rebamipide 300 mg three times daily for 7 consecutive days. The rebamipide group exhibited significant prevention of erythema in the antrum compared with the placebo group (p = 0.0393, respectively). Results for the body and fornix did not differ significantly between the placebo and rebamipide groups. In conclusion, short-term administration of low-dose aspirin induced slight gastric mucosal injury in the antrum, but not in the body or fornix. Rebamipide may be useful for preventing low-dose aspirin-induced gastric mucosal injury, especially which confined to the antrum.
虽然低剂量阿司匹林被广泛应用，因为它是一种廉价且有效的预防心血管事件的手段，但它会引起胃肠道出血性并发症。本研究旨在评估瑞巴派特预防低剂量阿司匹林引起的胃损伤的疗效。在 20 名健康志愿者中进行了一项随机、双盲、安慰剂对照、交叉试验。连续 7 天，志愿者每日服用 81mg 阿司匹林和安慰剂或瑞巴派特 300mg，每日 3 次。与安慰剂组相比，瑞巴派特组的胃窦红斑显著预防（p=0.0393）。胃体和胃角两组之间的结果无显著差异。总之，短期低剂量阿司匹林给药会引起胃窦黏膜轻微损伤，但不会引起胃体或胃角损伤。瑞巴派特可能有助于预防低剂量阿司匹林引起的胃黏膜损伤，特别是局限于胃窦的损伤。
