Endoscopy Center, Tokyo Medical University Hospital, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
J Clin Biochem Nutr. 2011 Sep;49(2):136-40. doi: 10.3164/jcbn.11-10. Epub 2011 Aug 25.
It is well-known that acetylsalicylic acid induces gastrointestinal complication. Recently, trefoil factor family has been reported as a mucosal protective factor. We focused on trefoil factor family as one of defensive system for gastrointestinal injuries. The aim of this trial was to evaluate trefoil factor family levels in the serum of healthy subjects with low-dose acetylsalicylic acid. Low-dose acetylsalicylic acid with placebo or proton pump inhibitor or rebamipide were administered in 30 healthy subjects. Transnasal endoscopy was performed at 0, 24 h, 3 and 7 day. Changing of trefoil factor family (1,2,3) and numbers of gastric injuries were evaluated. The numbers of gastric injuries were significantly increased in the placebo group at 3 and 7 days. Injuries in the proton pump inhibitor group were not induced, in the rebamipide group were slightly induced. Trefoil factor family level in the placebo group were decreased in 3 and 7 days compared with prior to starting the trial. Trefoil factor family may have an important association with acetylsalicylic acid-induced gastrointestinal damage. Proton pump inhibitor and rebamipide prevented low-dose acetylsalicylic acid-induced gastrointestinal complications compared with the placebo group.
众所周知，乙酰水杨酸会引起胃肠道并发症。最近，三叶因子家族已被报道为一种黏膜保护因子。我们将三叶因子家族作为胃肠道损伤防御系统之一进行了研究。本试验旨在评估低剂量乙酰水杨酸对健康受试者血清三叶因子家族水平的影响。30 名健康受试者分别给予低剂量乙酰水杨酸+安慰剂、质子泵抑制剂或瑞巴派特，于 0、24h、3d 和 7d 行经鼻内镜检查，评估三叶因子家族（1、2、3）变化和胃损伤数量。安慰剂组在 3d 和 7d 时胃损伤数量明显增加，质子泵抑制剂组未诱导出损伤，瑞巴派特组仅轻度诱导出损伤。与试验前相比，安慰剂组在 3d 和 7d 时三叶因子家族水平降低。三叶因子家族可能与乙酰水杨酸引起的胃肠道损伤有重要关系。与安慰剂组相比，质子泵抑制剂和瑞巴派特可预防低剂量乙酰水杨酸引起的胃肠道并发症。
