文献检索
文档翻译
深度研究
学术资讯

Zotero 插件

邀请有礼
套餐&价格
历史记录

应用&插件

Zotero 插件浏览器插件 Mac 客户端 Windows 客户端微信小程序

定价

高级版会员购买积分包购买API积分包

服务

文献检索文档翻译深度研究 API 文档 MCP 服务

关于我们

关于 Suppr 公司介绍联系我们用户协议隐私条款

关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究

粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.合成及五氟硫基美福君的第一个类似物的生物评价。

Org Biomol Chem. 2009 Oct 21;7(20):4163-5. doi: 10.1039/b911483a. Epub 2009 Aug 7.

2

Synthesis, antimalarial activity, and intracellular targets of MEFAS, a new hybrid compound derived from mefloquine and artesunate.甲氟喹和青蒿琥酯衍生的新型杂合化合物MEFAS的合成、抗疟活性及细胞内靶点

Antimicrob Agents Chemother. 2008 Nov;52(11):3868-74. doi: 10.1128/AAC.00510-08. Epub 2008 Aug 18.

3

Utility of alkylaminoquinolinyl methanols as new antimalarial drugs.烷基氨基喹啉基甲醇作为新型抗疟药物的效用。

Antimicrob Agents Chemother. 2006 Dec;50(12):4132-43. doi: 10.1128/AAC.00631-06. Epub 2006 Sep 11.

4

The antimalarial potential of 4-quinolinecarbinolamines may be limited due to neurotoxicity and cross-resistance in mefloquine-resistant Plasmodium falciparum strains.由于对甲氟喹耐药的恶性疟原虫菌株存在神经毒性和交叉耐药性，4-喹啉甲醇胺的抗疟潜力可能有限。

Antimicrob Agents Chemother. 2004 Jul;48(7):2624-32. doi: 10.1128/AAC.48.7.2624-2632.2004.

5

Synthesis and Antimalarial Activity of New Enantiopure Aminoalcoholpyrrolo[ 1,2-a]quinoxalines.新型对映体纯氨基醇吡咯并[1,2-a]喹喔啉的合成及其抗疟活性

Med Chem. 2018;14(3):293-303. doi: 10.2174/1573406413666170726123938.

6

A Review of Modifications of Quinoline Antimalarials: Mefloquine and (hydroxy)Chloroquine.喹啉类抗疟药的修饰综述：甲氟喹和（羟基）氯喹。

Molecules. 2022 Feb 2;27(3):1003. doi: 10.3390/molecules27031003.

7

Synthetic ferrocenic mefloquine and quinine analoguesas potential antimalarial agents.合成二茂铁甲氟喹和奎宁类似物作为潜在抗疟药

Eur J Med Chem. 2000 Jul-Aug;35(7-8):707-14. doi: 10.1016/s0223-5234(00)00178-1.

8

Novel molecule combinations and corresponding hybrids targeting artemisinin-resistant Plasmodium falciparum parasites.针对耐青蒿素疟原虫的新型分子组合和相应的杂种。

Bioorg Med Chem Lett. 2021 May 1;39:127884. doi: 10.1016/j.bmcl.2021.127884. Epub 2021 Feb 24.

9

Synthesis and biological evaluation of new imidazo[1,2-a]pyridine derivatives designed as mefloquine analogues.

Farmaco. 2002 Oct;57(10):825-32. doi: 10.1016/s0014-827x(02)01304-6.

10

Design, synthesis and antimalarial activity of trifluoromethylartemisinin-mefloquine dual molecules.三氟甲基青蒿素-甲氟喹双分子的设计、合成及抗疟活性

Chembiochem. 2005 Apr;6(4):648-52. doi: 10.1002/cbic.200400347.

引用本文的文献

1

Activation and Catalytic Degradation of SF and PhSF at a Bismuth Center.铋中心处SF和PhSF的活化与催化降解

J Am Chem Soc. 2024 Sep 18;146(37):25409-25415. doi: 10.1021/jacs.4c07044. Epub 2024 Sep 3.

2

Overcoming a Radical Polarity Mismatch in Strain-Release Pentafluorosulfanylation of [1.1.0]Bicyclobutanes: An Entryway to Sulfone- and Carbonyl-Containing SF-Cyclobutanes.克服[1.1.0]双环丁烷应变释放五氟硫烷基化中的极端极性不匹配：通往含砜基和羰基的SF-环丁烷的途径。

Angew Chem Int Ed Engl. 2024 May 6;63(19):e202319930. doi: 10.1002/anie.202319930. Epub 2024 Mar 28.

3

Strain-Release Pentafluorosulfanylation and Tetrafluoro(aryl)sulfanylation of [1.1.1]Propellane: Reactivity and Structural Insight.

本文引用的文献

1

Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century.N-叔丁基异喹啉（GSK369796）的候选药物选择和临床前评估，一种负担得起且有效的 21 世纪 4-氨基喹啉抗疟药。

J Med Chem. 2009 Mar 12;52(5):1408-15. doi: 10.1021/jm8012618.

2

Antimalarial activity of phenylthiazolyl-bearing hydroxamate-based histone deacetylase inhibitors.含苯并噻唑基的异羟肟酸类组蛋白去乙酰化酶抑制剂的抗疟活性

Antimicrob Agents Chemother. 2008 Oct;52(10):3467-77. doi: 10.1128/AAC.00439-08. Epub 2008 Jul 21.

3

The synthesis and biological activity of pentafluorosulfanyl analogs of fluoxetine, fenfluramine, and norfenfluramine.

[1.1.1]三叶烷的应变释放五氟硫基化和四氟（芳基）硫基化：反应性和结构洞察。

Angew Chem Int Ed Engl. 2022 Nov 25;61(48):e202211892. doi: 10.1002/anie.202211892. Epub 2022 Oct 25.

4

(Hetero)aryl-S Fluorides: Synthetic Development and Opportunities.杂芳基氟化物：合成发展与机遇

Angew Chem Int Ed Engl. 2022 Jun 7;61(23):e202200904. doi: 10.1002/anie.202200904. Epub 2022 Apr 27.

5

Chemical modulation of Kv7 potassium channels.Kv7钾通道的化学调节

RSC Med Chem. 2021 Jan 14;12(4):483-537. doi: 10.1039/d0md00328j. eCollection 2021 Apr 28.

6

Amine-borane complex-initiated SFCl radical addition on alkenes and alkynes.胺硼烷络合物引发的SFCl自由基对烯烃和炔烃的加成反应。

Beilstein J Org Chem. 2020 Dec 16;16:3069-3077. doi: 10.3762/bjoc.16.256. eCollection 2020.

7

6-Amino[1,2,5]oxadiazolo[3,4-]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis.6-氨基[1,2,5]恶二唑并[3,4-b]吡嗪-5-醇衍生物作为非酒精性脂肪性肝炎 STAM 小鼠模型中有效的线粒体解偶联剂。

J Med Chem. 2020 Jun 11;63(11):6203-6224. doi: 10.1021/acs.jmedchem.0c00542. Epub 2020 May 27.

8

Structural characterization and Hirshfeld surface analysis of 2-iodo-4-(penta-fluoro-λ-sulfan-yl)benzo-nitrile.2-碘-4-(五氟-λ-硫烷基)苯甲腈的结构表征与 Hirshfeld 表面分析

Acta Crystallogr E Crystallogr Commun. 2020 Jan 17;76(Pt 2):231-234. doi: 10.1107/S2056989020000365. eCollection 2020 Feb 1.

9

Synthesis and Optimization of K7 (KCNQ) Potassium Channel Agonists: The Role of Fluorines in Potency and Selectivity.K7（KCNQ）钾通道激动剂的合成与优化：氟在效力和选择性中的作用

ACS Med Chem Lett. 2019 May 8;10(6):929-935. doi: 10.1021/acsmedchemlett.9b00097. eCollection 2019 Jun 13.

10

Synthesis of Phthalocyanines with a Pentafluorosulfanyl Substituent at Peripheral Positions.外周位置带有五氟硫烷基取代基的酞菁的合成。

ChemistryOpen. 2015 Jul 24;4(6):698-702. doi: 10.1002/open.201500165. eCollection 2015 Dec.

氟西汀、芬氟拉明和去甲芬氟拉明的五氟硫烷基类似物的合成及生物活性

Bioorg Med Chem. 2007 Nov 1;15(21):6659-66. doi: 10.1016/j.bmc.2007.08.012. Epub 2007 Aug 15.

4

Self-assembled organic monolayers terminated in perfluoroalkyl pentafluoro-lambda(6)-sulfanyl (-SF5) chemistry on gold.在金表面以全氟烷基五氟-λ(6)-硫烷基（-SF5）化学为终端的自组装有机单分子层。

Langmuir. 2004 Jul 6;20(14):5776-81. doi: 10.1021/la040011w.

5

Medical need, scientific opportunity and the drive for antimalarial drugs.医疗需求、科学机遇与抗疟药物的研发动力

Nature. 2002 Feb 7;415(6872):686-93. doi: 10.1038/415686a.

6

Chemical insights from high-resolution X-ray photoelectron spectroscopy and ab initio theory: propyne, trifluoropropyne, and ethynylsulfur pentafluoride.

J Am Chem Soc. 2001 Oct 31;123(43):10729-37. doi: 10.1021/ja016395j.

7

Methyl- and (Trifluoromethyl)alkene Peptide Isosteres: Synthesis and Evaluation of Their Potential as beta-Turn Promoters and Peptide Mimetics.

J Org Chem. 1998 Sep 4;63(18):6088-6089. doi: 10.1021/jo981057v.

8

Cerebral uptake of mefloquine enantiomers in fatal cerebral malaria.甲氟喹对映体在致死性脑型疟中的脑摄取情况。

Int J Clin Pharmacol Ther. 1999 Jan;37(1):58-61.

9

Quinoline antimalarials: mechanisms of action and resistance and prospects for new agents.喹啉类抗疟药：作用机制、耐药性及新型药物前景

Pharmacol Ther. 1998 Jul;79(1):55-87. doi: 10.1016/s0163-7258(98)00012-6.

10

Modulation of the function of human MDR1 P-glycoprotein by the antimalarial drug mefloquine.

Biochem Pharmacol. 1996 Nov 22;52(10):1545-52. doi: 10.1016/s0006-2952(96)00556-4.

合成及五氟硫基美福君的第一个类似物的生物评价。 - Suppr | 超能文献

合成及五氟硫基美福君的第一个类似物的生物评价。

Synthesis and biological evaluation of the first pentafluorosulfanyl analogs of mefloquine.

机构信息

Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

出版信息

Org Biomol Chem. 2009 Oct 21;7(20):4163-5. doi: 10.1039/b911483a. Epub 2009 Aug 7.

DOI:10.1039/b911483a

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2929370/

Abstract

Two novel SF5 analogs of the antimalarial agent mefloquine were synthesized in 5 steps and 10-23% overall yields and found to have improved activity and selectivity against malaria parasites. This work also represents the first report of SF5-substituted quinolines.

摘要

两种新型 SF5 类似物的抗疟药物甲氟喹在 5 步反应中合成，总产率为 10-23%，发现对疟原虫具有更好的活性和选择性。这项工作也代表了 SF5 取代喹啉的首次报道。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/ecaa2efcddac/nihms224679f5.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/35929094f6fe/nihms224679f1.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/42db90bfea9b/nihms224679f2.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/bd4f0812237b/nihms224679f3.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/08c5563230ce/nihms224679f4.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/ecaa2efcddac/nihms224679f5.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/35929094f6fe/nihms224679f1.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/42db90bfea9b/nihms224679f2.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/bd4f0812237b/nihms224679f3.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/08c5563230ce/nihms224679f4.jpg

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f5e8/2929370/ecaa2efcddac/nihms224679f5.jpg