Nagaty Ibraheim M, Ibrahim Khadra M, Abdel-Tawab Ahmad H, Hassan Alaa-Eldin A
Department of Parasitology, Faculty of Medicine, Universities of Benha, Benha, Egypt.
J Egypt Soc Parasitol. 2009 Aug;39(2):625-32.
Congenital Toxoplasma gondii infection may lead to abortion, stillbirth, neonatal death as well as severe congenital toxoplasmosis in the newborn infants. No doubt, early and proper diagnosis of infection pregnant women or her baby pave the way to effective treatment and minimize complications. In this study; the PCR and ELISA-IgM were used to diagnose active toxoplasmosis. The results revealed that PCR detected very recently infection (23/70 subjects) than ELISA-IgM (18/70 ones). However, the use of both ELISA-IgM and PCR together improved the diagnostic sensitivity and specificity.
先天性弓形虫感染可能导致流产、死产、新生儿死亡以及新生儿严重先天性弓形虫病。毫无疑问，对感染孕妇或其婴儿进行早期和恰当诊断可为有效治疗铺平道路并将并发症降至最低。在本研究中，采用聚合酶链反应（PCR）和酶联免疫吸附测定IgM（ELISA-IgM）来诊断活动性弓形虫病。结果显示，与ELISA-IgM（70例中的18例）相比，PCR检测出近期感染的病例更多（70例中的23例）。然而，同时使用ELISA-IgM和PCR可提高诊断的敏感性和特异性。
