Jost S, Reuner C, Mohadjer M, Mundinger F, Cramer H
Department of Neurology, Freiburg, W. Germany.
Neuropeptides. 1990 Apr;15(4):219-25. doi: 10.1016/0143-4179(90)90016-r.
We have measured somatostatin-like immunoreactivity SLI in cerebroventricular fluid of patients with Parkinson's disease (PD) and other extrapyramidal disorders with hyperkinesia. Patients with PD showed a significantly lower concentration of SLI when compared with levels in control patients with chronic stable multiple sclerosis or temporal lobe epilepsy. Less markedly decreased levels of SLI were also noted in patients with torsion dystonia. Of two patients with Huntington's disease one showed a high and one a medium concentration of SLI. According to the site of the stereotactic cannula, verified by ventriculopathy, SLI concentrations in CSF specimen obtained from the foramen Monro tended to be higher than in specimen from a supraforaminal level. Of 5 other patients with lateral and third ventricle being accessible during the passage of the stereotactic cannula, 4 showed higher SLI concentrations in the third ventricle compared to the lateral ventricle. High performance liquid chromatographic analysis combined with radioimmunoassay showed molecular heterogeneity of SLI in CSF. The ratio of SST-14 to SST-28 was higher in the third ventricle than in the lateral ventricle.
我们测量了帕金森病（PD）患者以及患有运动机能亢进的其他锥体外系疾病患者脑脊液中的生长抑素样免疫反应性（SLI）。与慢性稳定型多发性硬化症或颞叶癫痫的对照患者相比，PD患者的SLI浓度显著降低。扭转性肌张力障碍患者的SLI水平也有较轻微的降低。在两名亨廷顿病患者中，一名患者的SLI浓度较高，另一名患者的浓度中等。根据脑室造影证实的立体定向套管位置，从孟氏孔获取的脑脊液标本中的SLI浓度往往高于孔上水平的标本。在立体定向套管穿刺过程中可触及侧脑室和第三脑室的另外5名患者中，4名患者第三脑室的SLI浓度高于侧脑室。高效液相色谱分析结合放射免疫测定显示脑脊液中SLI存在分子异质性。第三脑室中SST - 14与SST - 28的比值高于侧脑室。
