Cramer H, Jost S, Reuner C, Milios E, Geiger J, Mundinger F
Department of Neurology, University of Freiburg, FRG.
Neuropeptides. 1991 Feb;18(2):69-73. doi: 10.1016/0143-4179(91)90002-z.
Substance P-like immunoreactivity (SPLI) was determined in cerebrovascular fluid of patients with extrapyramidal motor diseases. Patients with Parkinson's disease (PD) showed a SPLI concentration decreased by 30% compared with patients without extrapyramidal disease. No differences were apparent for patients with dystonia. Fluid obtained from the foramen Monro showed higher SPLI concentrations than fluid from a lateral ventricle, indicating that hypothalamic sources are important for ventricular substance P. Lateral ventricular SPLI was particularly low in parkinsonian patients which raises the possibility of a decreased SPergic activity in basal ganglia occurring in PD.
对锥体外系运动疾病患者的脑脊液中的P物质样免疫反应性（SPLI）进行了测定。帕金森病（PD）患者的SPLI浓度与无锥体外系疾病的患者相比降低了30%。肌张力障碍患者未显示出明显差异。从室间孔获取的脑脊液显示出比侧脑室脑脊液更高的SPLI浓度，表明下丘脑来源对脑室P物质很重要。帕金森病患者侧脑室的SPLI特别低，这增加了PD患者基底神经节中P物质能活性降低的可能性。
