Jephson Chris G, Manunza Francesca, Syed Samira, Mills Nikki A, Harper John, Hartley Ben E J
Department of Otolaryngology, Great Ormond Street Hospital for Children, Great Ormond Street, London WC1N 3JH, UK.
Int J Pediatr Otorhinolaryngol. 2009 Dec;73(12):1821-3. doi: 10.1016/j.ijporl.2009.08.020. Epub 2009 Sep 30.
Subglottic haemangioma is a rare but potentially life threatening condition which requires intervention. Many different treatments have been described with varying degrees of success and complications. Recently, successful treatment with propranolol has been reported in 11 cases of cutaneous haemangiomas and then in two cases of subglottic haemangiomas with extensive cutaneous lesions in conjunction with other treatment modalities. We describe the successful treatment with propranolol, of a stridulous four-month-old child with a 95% obstructing subglottic haemangioma. This was achieved without the need for tracheostomy or any other surgical intervention, and with no reported side effects. We now believe the new discovery of a dramatic response to propranolol allows treatment in the acute setting and following further study may render surgical treatment of subglottic haemangioma obsolete.
声门下血管瘤是一种罕见但可能危及生命的疾病，需要进行干预。已经描述了许多不同的治疗方法，其成功率和并发症程度各不相同。最近，有报道称普萘洛尔成功治疗了11例皮肤血管瘤，随后又成功治疗了2例伴有广泛皮肤病变的声门下血管瘤，并结合了其他治疗方式。我们描述了一名4个月大、因声门下血管瘤导致95%气道阻塞而出现喘鸣的患儿，使用普萘洛尔成功治疗的案例。该治疗无需气管切开术或任何其他手术干预，且未报告有副作用。我们现在认为，普萘洛尔产生显著疗效这一新发现使得在急性情况下即可进行治疗，并且经过进一步研究后，声门下血管瘤的手术治疗可能会过时。
