Goswamy J, Rothera M P, Bruce I A
Department of Paediatric Otorhinolaryngology, Royal Manchester Children's Hospital, UK.
J Laryngol Otol. 2011 Nov;125(11):1164-72. doi: 10.1017/S0022215111001538. Epub 2011 Aug 16.
Infantile haemangiomas enter a rapid proliferative phase within months of birth, before slowly involuting. Those with the potential for disfigurement or morbidity require intervention. Propranolol has emerged as an effective new treatment modality, with the potential to become the first-line treatment of choice.
Four children with haemangiomas of the head and neck were treated with propranolol at a tertiary referral centre. The size of the haemangioma and the symptoms resulting from airway compromise were monitored.
Three of the four children showed a dramatic response to treatment with propranolol. However, one child responded initially but was readmitted with stridor secondary to new haemangioma proliferation.
We report a cautionary case in which a subglottic haemangioma developed contemporaneously with propranolol treatment, requiring surgical intervention. This finding highlights the need for regular follow up of treatment response, and the need for monitoring for treatment side effects.
婴儿血管瘤在出生后的几个月内进入快速增殖期，随后逐渐缓慢消退。那些有可能导致毁容或发病的血管瘤需要进行干预。普萘洛尔已成为一种有效的新治疗方式，有可能成为一线治疗选择。
在一家三级转诊中心，对四名患有头颈部血管瘤的儿童使用普萘洛尔进行治疗。监测血管瘤的大小以及气道受压引起的症状。
四名儿童中有三名对普萘洛尔治疗表现出显著反应。然而，一名儿童最初有反应，但因新的血管瘤增殖导致喘鸣再次入院。
我们报告了一例警示性病例，即声门下血管瘤在普萘洛尔治疗期间同时出现，需要进行手术干预。这一发现凸显了定期随访治疗反应以及监测治疗副作用的必要性。
