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普萘洛尔治疗节段性血管瘤成功 1 例报告

Successful treatment with propranolol in a patient with a segmental hemangioma: a case report.

机构信息

Diyarbakır Children's Diseases Hospital, Department of Pediatric Oncology, Diyarbakır, Turkey.

Diyarbakır Children's Diseases Hospital, Department of Pediatric Cardiology, Diyarbakır, Turkey.

出版信息

Turk J Haematol. 2012 Jun;29(2):170-3. doi: 10.5505/tjh.2012.37233. Epub 2012 Jun 15.

Abstract

The treatment of hemangiomas in infancy may be associated with significant morbidity. In addition to morbidity, an objective response cannot be obtained because of the absence of targeted therapeutic options. Herein, we present an infant with a segmental hemangioma and marked glucocorticoid toxicity due to prior steroid therapy that was successfully treated with propranolol. Propranolol was tolerated well and no side effects were observed during the treatment. The only problem to occur was disease recurrence following the withdrawal of propranolol at age 13 months, which was not within the age of spontaneous regression (generally considered as >18 months).

摘要

婴儿期血管瘤的治疗可能与显著的发病率有关。除了发病率之外,由于缺乏靶向治疗选择,也无法获得客观的反应。在此,我们介绍了一名婴儿患有节段性血管瘤,由于先前的类固醇治疗导致明显的糖皮质激素毒性,使用普萘洛尔成功治疗。普萘洛尔耐受性良好,治疗过程中未观察到任何副作用。唯一出现的问题是在 13 个月大时停用普萘洛尔后疾病复发,这不在自发消退的年龄范围内(一般认为 >18 个月)。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3d47/3986956/ae2f74efe6d9/TJH-29-170-g1.jpg

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