Integrin proteomes reveal a new guide for cell motility.

Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation-2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.