Danen Erik H J
Leiden Amsterdam Center for Drug Research, Leiden University, Netherlands.
Sci Signal. 2009 Sep 22;2(89):pe58. doi: 10.1126/scisignal.289pe58.
Integrin transmembrane receptors orchestrate signaling cascades by recruiting cytoskeletal linker proteins and enzymes to sites of cell adhesion. A proteomics-based view of such integrin-associated signaling networks is now available. Besides the usual suspects, the interactomes contain several proteins that were not previously connected to integrins. One of these, regulator of chromosome condensation-2 (RCC2), represents an unexpected molecular connection between integrins and the cell-migration machinery.
整合素跨膜受体通过招募细胞骨架连接蛋白和酶到细胞粘附位点来协调信号级联反应。现在已有基于蛋白质组学的此类整合素相关信号网络的观点。除了常见的嫌疑蛋白外，相互作用组还包含几种以前未与整合素相关联的蛋白质。其中之一，染色体凝聚调节因子2（RCC2），代表了整合素与细胞迁移机制之间意想不到的分子联系。
