Guo Kun, Zhao Cheng, Lang Bin, Wang Huiqin, Zheng Hang, Zhang Feng
College of Life Sciences, Shanghai Normal University, Shanghai, China.
Front Mol Biosci. 2021 Jan 13;7:620973. doi: 10.3389/fmolb.2020.620973. eCollection 2020.
Accurate regulation of cell cycle is important for normal tissue development and homeostasis. RCC2 (Regulator of Chromosome Condensation 2) play a role as chromosomal passenger complex (CPC) implicated in all cell cycle phases. RCC2 was initially identified as Ran guanine exchange factor (GEF) for small G proteins. Therefore, RCC2 plays a key role in oncogenesis of most cancers. RCC2 is implicated in Colorectal Cancer (CRC), Lung Adenocarcinoma (LUAD), breast cancer, and ovarian cancer. Expression level of RCC2 protein determines regulation of tumor cell proliferation, invasion, metastasis, and radio-chemotherapeutic resistance. In this review, we explored proteins that interact with RCC2 to modulate tumor development and cancer therapeutic resistance by regulation of cell cycle process through various signaling pathways.
细胞周期的精确调控对于正常组织发育和体内平衡至关重要。染色体凝聚调节因子2（RCC2）作为参与所有细胞周期阶段的染色体乘客复合体（CPC）发挥作用。RCC2最初被鉴定为小G蛋白的Ran鸟嘌呤交换因子（GEF）。因此，RCC2在大多数癌症的肿瘤发生中起关键作用。RCC2与结直肠癌（CRC）、肺腺癌（LUAD）、乳腺癌和卵巢癌有关。RCC2蛋白的表达水平决定了肿瘤细胞增殖、侵袭、转移和放化疗耐药性的调控。在本综述中，我们探讨了与RCC2相互作用的蛋白质，这些蛋白质通过各种信号通路调节细胞周期进程来调节肿瘤发展和癌症治疗耐药性。
