Department of Bioengineering, University of California, Berkeley, 174 Stanley Hall, Berkeley, CA 94720-1762, USA.
J Mol Cell Biol. 2010 Feb;2(1):1-4. doi: 10.1093/jmcb/mjp027. Epub 2009 Sep 30.
A popular theory in the stem cell field is that 'regeneration recapitulates development', or that adult stem cells function similarly to embryonic ones. In a recent Nature article, Lepper et al. questioned this approach, highlighting the differences in requirements for Pax7 during myogenesis for embryonic, juvenile and adult muscle.
干细胞领域的一个流行理论是“再生再现发育”，或者说成体干细胞的功能类似于胚胎干细胞。在最近的一篇《自然》杂志文章中，Lepper 等人对这种方法提出了质疑，强调了 Pax7 在胚胎、幼年和成年肌肉的成肌发生过程中的需求存在差异。
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