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68Ga-氯化物 PET 揭示了大鼠中的人胰腺腺癌异种移植物——与 FDG 的比较。

68Ga-chloride PET reveals human pancreatic adenocarcinoma xenografts in rats--comparison with FDG.

机构信息

Turku PET Centre, Turku University Hospital, 20521, Turku, Finland.

出版信息

Mol Imaging Biol. 2010 Jun;12(3):259-68. doi: 10.1007/s11307-009-0267-3. Epub 2009 Oct 2.

DOI:10.1007/s11307-009-0267-3
PMID:19798536
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2864902/
Abstract

PURPOSE

The aim of the study was to compare (68)Ga-chloride with 2-[(18)F]fluoro-2-deoxy-D: -glucose (FDG) for the imaging of pancreatic xenografts.

PROCEDURES

Rats with subcutaneous human pancreatic adenocarcinoma xenografts were evaluated in vivo by dynamic positron emission tomography (PET) and ex vivo by measuring radioactivity of excised tissues and by digital autoradiography of tumor cryosections.

RESULTS

Both tracers were capable of delineating all subcutaneous tumors from surrounding tissues by PET. The standardized uptake values of tumors by PET were 0.9 +/- 0.3 (mean +/- SD) for (68)Ga-chloride (n = 13) and 1.8 +/- 1.2 for FDG (n = 11). Ex vivo studies showed tumor-to-muscle ratio of 4.0 +/- 0.3 for (68)Ga-chloride (n = 4) and 7.9 +/- 3.2 for FDG (n = 4).

CONCLUSIONS

(68)Ga-chloride delineated subcutaneously implanted pancreatic adenocarcinoma xenografts by PET, but the uptake was lower than FDG. Further studies to clarify the value of (68)Ga-chloride for PET imaging of tumors are warranted.

摘要

目的

本研究旨在比较氯化（68）Ga 和 2-[(18)F]氟-2-脱氧-D: -葡萄糖（FDG）在胰腺异种移植瘤成像中的应用。

方法

通过动态正电子发射断层扫描（PET）对皮下人胰腺腺癌异种移植瘤大鼠进行体内评估，并通过测量切除组织的放射性活度和肿瘤冷冻切片的数字放射自显影进行离体评估。

结果

两种示踪剂均能通过 PET 从周围组织中清晰勾画所有皮下肿瘤。PET 测定的肿瘤标准化摄取值分别为（68）Ga 氯化物组（n = 13）0.9 +/- 0.3 和 FDG 组（n = 11）1.8 +/- 1.2。离体研究显示，（68）Ga 氯化物组（n = 4）肿瘤与肌肉的比值为 4.0 +/- 0.3，FDG 组（n = 4）为 7.9 +/- 3.2。

结论

（68）Ga 氯化物通过 PET 描绘了皮下植入的胰腺腺癌异种移植瘤，但摄取量低于 FDG。进一步研究（68）Ga 氯化物对肿瘤 PET 成像的价值是必要的。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/2f35b8da5a12/11307_2009_267_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/38ab8551103e/11307_2009_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/5f29b0aaeb2a/11307_2009_267_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/dd015d49c958/11307_2009_267_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/8e57f40021be/11307_2009_267_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/51eea74dbca6/11307_2009_267_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/109966be677f/11307_2009_267_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/2f35b8da5a12/11307_2009_267_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/38ab8551103e/11307_2009_267_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/5f29b0aaeb2a/11307_2009_267_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/dd015d49c958/11307_2009_267_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/8e57f40021be/11307_2009_267_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/51eea74dbca6/11307_2009_267_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/109966be677f/11307_2009_267_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e62f/2864902/2f35b8da5a12/11307_2009_267_Fig7_HTML.jpg

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