Kang Yu-Hoi, Tan Lee Aun, Carroll Maria V, Gentle Madeleine E, Sim Robert B
MRC Immunochemistry Unit, Department of Biochemistry, University of Oxford, Oxford, UK.
Adv Exp Med Biol. 2009;653:117-28. doi: 10.1007/978-1-4419-0901-5_8.
The complement system is a major component of the innate defence of animals against invading microorganisms, and is also essential for the recognition and clearance of damaged or structurally-altered host cells or macromolecules. The system is activated by three different pathways, each of which responds, using different recognition molecules, to a very wide range of activators. The recognition protein of the complement classical pathway, C1q is described in detail here, with comparisons to the alternative pathway.
补体系统是动物抵御入侵微生物固有防御的主要组成部分，对于识别和清除受损或结构改变的宿主细胞或大分子也至关重要。该系统通过三种不同途径激活，每种途径利用不同的识别分子对非常广泛的激活物作出反应。本文详细描述了补体经典途径的识别蛋白C1q，并与替代途径进行了比较。
