Ivanov A A, Ulanova A M, Stavrakova N M, Deshevoĭ Iu B, Nasonova T A, Koterov A N, Gutsenko K K, Mal'tsev V N
Radiats Biol Radioecol. 2009 Jul-Aug;49(4):456-61.
The propose of these examination was studied antiradiation effect of lactoferrin (LF). It was determined, that subcutaneous injection LF (65 or 300 mkg/kg) guinea-pigs irradiated after 1-14 days after of total gamma-irradiation (2.5 Gr) had therapeutically effect attached to the bone marrow form of acute radiation disease (ARD). This effect was explained in increase of survive the animals with 53.8% to 92.8% and stimulation erythropoiesis, judge by number of reticulocytes and increase neutrophiles (12 days ARD) and lymphocytes (12 and 16 days ARD) by comparison with control animals. LF had no effect attached to intestinal form of acute radiation disease by mice. The injection of LF before total irradiation rats of electrons (energy 25 MeV) in doses 255 Gr decreased expression of some symptom of cerebral form of acute radiation disease: prolong time of beginning convulsive period with 5.7 hours to 14.1 hours and duration of life with 7.7 hours to 15.3 hours. LF had antioxidative activity.
这些实验的目的是研究乳铁蛋白（LF）的抗辐射作用。结果表明，在豚鼠全身γ射线照射（2.5戈瑞）后1至14天，皮下注射LF（65或300微克/千克）对急性放射病（ARD）的骨髓型具有治疗作用。这种作用表现为动物存活率从53.8%提高到92.8%，并刺激红细胞生成，从网织红细胞数量以及与对照动物相比中性粒细胞（ARD 12天）和淋巴细胞（ARD 12天和16天）数量的增加可以判断。LF对小鼠急性放射病的肠道型没有作用。在大鼠接受总剂量为255戈瑞的电子照射（能量25兆电子伏）前注射LF，可减轻急性放射病脑型的一些症状：惊厥期开始时间从5.7小时延长至14.1小时，生存期从7.7小时延长至15.3小时。LF具有抗氧化活性。
