Department of Radiation Medicine, Faculty of Naval Medicine, Second Military Medical University, Shanghai, PR China.
Free Radic Res. 2010 Mar;44(3):275-82. doi: 10.3109/10715760903468758.
It has been demonstrated that hydrogen can selectively reduce hydroxyl and peroxynitrite in vitro. Since most of the ionizing radiation-induced cellular damage is caused by hydroxyl radicals, this study was designed to test the hypothesis that hydrogen may be an effective radioprotective agent. This paper demonstrates that treating cells with hydrogen before irradiation could significantly inhibit ionizing irradiation(IR)-induced Human Lymphocyte AHH-1 cells apoptosis and increase cells viability in vitro. This paper also shows that hydrogen can protect gastrointestinal endothelia from radiation-induced injury, decrease plasma malondialdehyde (MDA) intestinal 8-hydroxydeoxyguanosine (8-OHDG) levels and increase plasma endogenous antioxidants in vivo. It is suggested that hydrogen has a potential as an effective and safe radioprotective agent.
已经证实氢气可以在体外选择性地还原羟自由基和过氧亚硝酸盐。由于大多数电离辐射引起的细胞损伤是由羟自由基引起的，因此本研究旨在检验氢气可能是一种有效的辐射防护剂的假说。本文证明，在辐照前用氢气处理细胞可显著抑制电离辐射（IR）诱导的人淋巴细胞 AHH-1 细胞凋亡，并增加体外细胞活力。本文还表明，氢气可以保护胃肠道内皮免受辐射损伤，降低血浆丙二醛（MDA）和肠 8-羟基脱氧鸟苷（8-OHDG）水平，并增加体内内源性抗氧化剂。这表明氢气具有作为一种有效且安全的辐射防护剂的潜力。
