López Moratalla Natalia
Departamento Interfacultativo de Bioquímica y Biología Molecular, Universidad de Navarra, 31080 Pamplona. Spain.
Cuad Bioet. 2009 Sep-Dec;20(70):471-85.
The legal possibility of using federal funds to work with embryonic cells and destroy embryos started on March 2009 in the USA. It has nothing to do with regenerative therapies. It is directed to create banks with human cells, banks directed by a few scientists involved in biotechnology enterprises connected with centers of in vitro reproduction. They pursue the use of ad hoc human embryos for biomedical research. The idea of using cell lines derived from embryos is quite spread, and even the idea of obtaining new lines of this type to validate reprogrammed somatic pluripotential cells, the so called iPS cell (induced pluripotent stem), without destroying embryos or using ovules. This type of cells is indeed of great value in medical research and it is opening new possibilities in Cell Therapy. Recent data are analyzed and considerations are advanced encouraging rational alternatives to eliminate embryonic cells in the evaluation of iPS cells.
在美国，2009年3月开始出现了使用联邦资金研究胚胎细胞并破坏胚胎的法律可能性。这与再生疗法毫无关系。其目的是创建人类细胞库，这些细胞库由一些参与生物技术企业且与体外生殖中心有关联的科学家负责。他们寻求将特定的人类胚胎用于生物医学研究。使用源自胚胎的细胞系这一想法相当普遍，甚至还有获取此类新细胞系以验证重编程的体细胞多能性细胞（即所谓的诱导多能干细胞，iPS细胞）的想法，而无需破坏胚胎或使用卵子。这类细胞在医学研究中确实具有巨大价值，并且为细胞治疗开辟了新的可能性。本文分析了近期数据并提出了相关思考，鼓励在评估iPS细胞时采用合理的替代方法以消除胚胎细胞的使用。
