Kirana H, Srinivasan B P
Delhi Institute of Pharmaceutical Sciences and Research, Sector-III, Pushp Vihar, New Delhi 110017, India.
Indian J Exp Biol. 2010 May;48(5):499-502.
In view of multi-dimensional activity of plant drugs beneficial to complex disorders like diabetes, the present study has been undertaken to evaluate the effect of aqueous extract of C. peltata roots on serum glucose, lipid profile, insulin, inflammatory marker namely tumour necrosis factor (TNF)-alpha and muscle glycogen in type 2 diabetic rats. Aqueous extract of C. peltata at 40 and 60 mg/kg dose significantly decreased both the fasting and postprandial blood glucose of type 2 diabetic rats; 60 mg/kg dose having more pronounced effect on hyperglycemia. An enhanced insulin levels by the aqueous extract is primary for its glucose and lipid lowering activity. The extract significantly decreased the elevated TNF-alpha in type 2 diabetic rats. The extract at 40 and 60 mg/kg dose increased the glycogen levels in skeletal muscle by 58 and 60% respectively. Improved glycogen in peripheral tissue such as skeletal muscle indicates the ability of plant drug to combat insulin resistance of type 2 diabetes.
鉴于植物药对糖尿病等复杂疾病具有多维度活性，本研究旨在评估盾叶薯蓣根水提取物对2型糖尿病大鼠血清葡萄糖、血脂谱、胰岛素、炎症标志物即肿瘤坏死因子（TNF）-α和肌肉糖原的影响。40和60mg/kg剂量的盾叶薯蓣水提取物显著降低了2型糖尿病大鼠的空腹和餐后血糖；60mg/kg剂量对高血糖的作用更显著。水提取物提高胰岛素水平是其降低血糖和血脂活性的主要原因。该提取物显著降低了2型糖尿病大鼠中升高的TNF-α。40和60mg/kg剂量的提取物分别使骨骼肌中的糖原水平提高了58%和60%。骨骼肌等外周组织中糖原的改善表明植物药具有对抗2型糖尿病胰岛素抵抗的能力。
