Jorens Philippe G, Van den Eynden Gert G
Department of Critical Care Medicine, Antwerp University Hospital, University of Antwerp, Edegem, Belgium.
Am J Cardiol. 2009 Oct 15;104(8):1160-2. doi: 10.1016/j.amjcard.2009.05.065.
Propofol is a potent and widely used central-acting sedative drug. It has been implicated in the development of a usually fatal syndrome characterized by metabolic acidosis, rhabdomyolysis, ventricular arrhythmia, and Brugada-like cardiac rhythm disturbances, all leading to cardiac and renal failure. The investigators describe a 12-year-old male patient with a fatal case of this so-called propofol infusion syndrome. Postmortem investigation showed not only the well-known myocytolysis in skeletal and cardiac muscle but also not previously demonstrated widespread fat accumulation in the myocardium. In conclusion, this cardiac fat accumulation illustrates the proposed underlying pathophysiology of impaired (muscular) free fatty acid utilization.
丙泊酚是一种强效且广泛使用的中枢性镇静药物。它与一种通常致命的综合征的发生有关，该综合征的特征为代谢性酸中毒、横纹肌溶解、室性心律失常以及类似 Brugada 综合征的心律紊乱，所有这些最终都会导致心脏和肾衰竭。研究人员描述了一名 12 岁男性患者，该患者死于这种所谓的丙泊酚输注综合征。尸检结果不仅显示出骨骼肌和心肌中众所周知的肌细胞溶解，还发现了此前未被证实的心肌广泛脂肪堆积。总之，这种心肌脂肪堆积说明了所提出的（肌肉）游离脂肪酸利用受损的潜在病理生理学机制。
