Institute of Clinical Pharmacology, Otto-von-Guericke University, Magdeburg, Germany.
Eur J Gastroenterol Hepatol. 2010 Jul;22(7):880-2. doi: 10.1097/MEG.0b013e3283320129.
Persistent cough could be caused by various diseases such as postnasal drip syndrome, asthma and gastroesophageal reflux disease (GERD) or adverse event of drugs such as angiotensin-converting enzyme inhibitors. We report a case of persistent cough associated with high plasma levels of the proton pump inhibitor omeprazole in a patient with GERD. This case suggests cough as an adverse drug event to omeprazole, which is otherwise commonly prescribed for the management of GERD-related cough. Therefore, physicians should be aware of the onset or an exacerbation of cough during omeprazole therapy.
持续性咳嗽可能由多种疾病引起，如鼻后滴注综合征、哮喘和胃食管反流病（GERD），或者是血管紧张素转换酶抑制剂等药物的不良反应。我们报告了一例 GERD 患者持续性咳嗽与质子泵抑制剂奥美拉唑血浆水平升高相关的病例。该病例提示咳嗽是奥美拉唑的药物不良反应事件，而奥美拉唑通常被开处方用于治疗 GERD 相关咳嗽。因此，医生应注意在奥美拉唑治疗期间咳嗽的出现或加重。
