Neuhauser S, Palm F, Ambuehl F, Möstl E, Schwendenwein I, Aurich C
Centre for Artificial Insemination and Embryo Transfer, Section for Obstetrics, Gynaecology and Andrology, University of Veterinary Sciences, Veterinärplatz 1, 1210 Vienna, Austria.
Equine Vet J. 2009 Jul;41(6):572-7. doi: 10.2746/042516409x394481.
Mares with compromised pregnancies are often treated with altrenogest to prevent abortion. However, there is only limited information about effects on the foal when altrenogest treatment is continued during final maturation of the fetus.
To determine effects of altrenogest treatment during late gestation in mares on maturity, haematology changes, adrenocortical function and serum electrolytes in their newborn foals.
Six mares were treated with altrenogest (0.088 mg/kg bwt) once daily from Day 280 of pregnancy until foaling and 7 mares served as controls.
Foals born to altrenogest-treated mares had a significantly lower neutrophil/lymphocyte ratio on the first day after birth than control foals (P<0.05). Basal plasma cortisol concentrations immediately after birth were higher in foals of altrenogest-treated mares than in control foals (P<0.05). Cortisol release in response to exogenous adrenocorticotropic hormone (ACTH)--except for higher values 15 min after ACTH injection in foals of altrenogest-treated mares on Day 1--revealed no differences in adrenocortical function between the groups of foals. Plasma potassium concentration in foals from altrenogest-treated mares compared to control foals was significantly lower immediately after birth (P<0.05) and plasma ionised calcium concentration was significantly lower 3 h after birth (P = 0.01).
Altrenogest treatment of pregnant mares prolonged labour had no major effects on adrenocortical function in foals. A reduced neutrophil/lymphocyte ratio in these foals may suggest either immunomodulatory effects of altrenogest or dysmaturity of the foals.
妊娠出现问题的母马常使用烯丙孕素进行治疗以防止流产。然而，关于在胎儿最终成熟阶段持续使用烯丙孕素治疗对幼驹的影响，相关信息有限。
确定妊娠后期母马使用烯丙孕素治疗对其新生幼驹的成熟度、血液学变化、肾上腺皮质功能和血清电解质的影响。
6匹母马自妊娠第280天起至分娩每日一次接受烯丙孕素治疗（0.088 mg/kg体重），7匹母马作为对照。
烯丙孕素治疗母马所产幼驹出生后第一天的中性粒细胞/淋巴细胞比值显著低于对照幼驹（P<0.05）。烯丙孕素治疗母马所产幼驹出生后即刻的基础血浆皮质醇浓度高于对照幼驹（P<0.05）。除了在第1天烯丙孕素治疗母马所产幼驹注射促肾上腺皮质激素（ACTH）后15分钟时皮质醇释放量较高外，两组幼驹的肾上腺皮质功能在对ACTH的反应方面未显示出差异。与对照幼驹相比，烯丙孕素治疗母马所产幼驹出生后即刻的血浆钾浓度显著较低（P<0.05），出生后3小时的血浆离子钙浓度显著较低（P = 0.01）。
对妊娠母马使用烯丙孕素延长分娩对幼驹的肾上腺皮质功能无重大影响。这些幼驹中性粒细胞/淋巴细胞比值降低可能表明烯丙孕素具有免疫调节作用或幼驹发育不成熟。
